The pattern of amyloid accumulation in the brains of adults with Down syndrome

被引：111

作者：

Annus, Tiina ^{[1
]}

Wilson, Liam R. ^{[1
]}

Hong, Young T. ^{[2
]}

Acosta-Cabronero, Julio ^{[3
]}

Fryer, Tim D. ^{[2
]}

Cardenas-Blanco, Arturo ^{[3
]}

Smith, Robert ^{[2
]}

Boros, Istvan ^{[2
]}

Coles, Jonathan P. ^{[4
]}

Aigbirhio, Franklin I. ^{[2
]}

Menon, David K. ^{[4
]}

Zaman, Shahid H. ^{[1
,5
]}

Nestor, Peter J. ^{[3
]}

Holland, Anthony J. ^{[1
,5
]}

机构：

[1] Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge, England

[2] Univ Cambridge, Dept Clin Neurosci, Wolfson Brain Imaging Ctr, Cambridge Biomed Campus, Cambridge, England

[3] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[4] Univ Cambridge, Dept Med, Div Anaesthesia, Cambridge Biomed Campus, Cambridge CB2 2QQ, England

[5] Cambridgeshire & Peterborough NHS Fdn Trust, Fulbourn Hosp, Cambridge, England

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 05期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; Down syndrome; Amyloid; PIB; PET; Dementia; Striatum; Preclinical; POSITRON-EMISSION-TOMOGRAPHY; PITTSBURGH-COMPOUND-B; ALZHEIMERS-DISEASE; CORPUS STRIATUM; BETA PROTEIN; DEMENTIA; DEPOSITION; AGE; ASSOCIATION; PLAQUES;

D O I：

10.1016/j.jalz.2015.07.490

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Adults with Down syndrome (DS) invariably develop Alzheimer's disease (AD) neuropathology. Understanding amyloid deposition in DS can yield crucial information about disease pathogenesis. Methods: Forty-nine adults with DS aged 25-65 underwent positron emission tomography with Pittsburgh compound-B (PIB). Regional PIB binding was assessed with respect to age, clinical, and cognitive status. Results: Abnormal PIB binding became evident from 39 years, first in striatum followed by rostral prefrontal-cingulo-parietal regions, then caudal frontal, rostral temporal, primary sensorimotor and occipital, and finally parahippocampal cortex, thalamus, and amygdala. PM binding was related to age, diagnostic status, and cognitive function. Discussion: PIB binding in DS, first appearing in striatum, began around age 40 and was strongly associated with dementia and cognitive decline. The absence of a substantial time lag between amyloid accumulation and cognitive decline contrasts to sporadic/familial AD and suggests this population's suitability for an amyloid primary prevention trial. (C) 2015 The Authors. Published by Elsevier Inc. on behalf of Alzheimer's Association.

引用

页码：538 / 545

页数：8

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