Hypoglycemic and hypolipidemic effects of samnamul (shoot of Aruncus dioicus var. kamtschaticus Hara) in mice fed a high-fat/high-sucrose diet

被引：16

作者：

Kim, Jung-In ^{[1
]}

Yun, Jeong-A ^{[1
]}

Jeong, Yoo-Kyung ^{[1
]}

Baek, Hee-Jin ^{[1
]}

机构：

[1] Inje Univ, Sch Food & Life Sci, Dept Smart Foods & Drugs, 197 Inje Ro, Gimhae 50834, Gyeongsangnam D, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2018年 / 27卷 / 05期

关键词：

Aruncus dioicus var. kamtschaticus Hara; Glucose; Alpha-glucosidase; Triglyceride; Diabetes mellitus; INSULIN-RESISTANCE; ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; INHIBITORY-ACTIVITIES; IN-VITRO; DYSLIPIDEMIA; ADIPONECTIN; MYRICETIN; ACARBOSE; OBESITY;

D O I：

10.1007/s10068-018-0390-5

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The hypoglycemic and hypolipidemic effects of samnamul were investigated. The alpha-glucosidase inhibitory activity of samnamul in vivo was determined in normal mice. Oral administration of samnamul extract (500mg/kg) or acarbose (50mg/kg) significantly reduced the postprandial glucose response. The effects of chronic consumption of samnamul on fasting hyperglycemia and dyslipidemia were determined in C57BL/6J mice with diabetes mellitus induced by a high-fat/high-sucrose (HFHS) diet. Consumption of samnamul extract at 0.5% of the diet for 12weeks decreased serum glucose, triglyceride, and cholesterol levels, the homeostasis model assessment for insulin resistance index, and activities of maltase and sucrase in the small intestine. These results suggest that samnamul had hypoglycemic and hypolipidemic effects in an animal model of type 2 diabetes and that the hypoglycemic effect occurred partly via the inhibition of alpha-glucosidase activity.

引用

页码：1467 / 1473

页数：7

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