Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy

被引：145

作者：

Meidahl, Anders Christian ^{[1
,2
]}

Tinkhauser, Gerd ^{[1
,2
,3
,4
]}

Herz, Damian Marc ^{[2
]}

Cagnan, Hayriye ^{[1
,2
,5
]}

Debarros, Jean ^{[1
,2
]}

Brown, Peter ^{[1
,2
]}

机构：

[1] Univ Oxford, MRC, Brain Network Dynam Unit, Oxford, England

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Level 6,West Wing, Oxford OX3 9DU, England

[3] Bern Univ Hosp, Dept Neurol, Bern, Switzerland

[4] Univ Bern, Bern, Switzerland

[5] UCL, Inst Neurol, London, England

来源：

MOVEMENT DISORDERS | 2017年 / 32卷 / 06期

基金：

英国医学研究理事会;

关键词：

deep brain stimulation; Parkinson's disease; brain-computer interface; essential tremor; closed-loop; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; ESSENTIAL TREMOR; COORDINATED RESET; GLOBUS-PALLIDUS; BETA; BRADYKINESIA; MODULATION; AMPLITUDE; NEUROMODULATION;

D O I：

10.1002/mds.27022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease. Current developments focus on trying to widen the therapeutic window of DBS. Adaptive DBS (aDBS), where stimulation is dynamically controlled by feedback from biomarkers of pathological brain circuit activity, is one such development. Relevant biomarkers may be central, such as local field potential activity, or peripheral, such as inertial tremor data. Moreover, stimulation may be directed by the amplitude or the phase (timing) of the biomarker signal. In this review, we evaluate existing aDBS studies as proof-of-principle, discuss their limitations, most of which stem from their acute nature, and propose what is needed to take aDBS into a chronic setting. (C) 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society

引用

页码：810 / 819

页数：10

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