Decarboxylative C-H alkylation of heteroarenes by copper catalysis

被引：25

作者：

Zhu, Xiaolong ^{[1
]}

Li, Xuan ^{[1
]}

Li, Xuehao ^{[1
]}

Lv, Jian ^{[1
]}

Sun, Kai ^{[2
]}

Song, Xiuyan ^{[1
]}

Yang, Daoshan ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Key Lab Opt Elect Sensing & Analyt Chem Life Sci, MOE, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China

[2] YanTai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 12期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; REDOX-ACTIVE ESTERS; CARBOXYLIC-ACIDS; MERGING PHOTOREDOX; DIRECT ARYLATION; BENZOIC-ACIDS; BOND FUNCTIONALIZATIONS; N-OXIDES; LIGHT; METAL;

D O I：

10.1039/d1qo00210d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Versatile decarboxylative C-H alkylation of heteroarenes was accomplished. In the presence of Cu(OTf)(2) and 4,4 '-di-tert-butyl-2,2 '-bipyridine, a range of heteroarenes, such as imidazo[1,2-a]pyridines, 2-phenylbenzo[d]imidazo[2,1-b]thiazole, 2-phenylindolizine and 4H-chromen-4-one, can be alkylated using diverse alkyl carboxylic acids. This developed protocol will extend the still limited number of copper catalytic decarboxylation couplings, especially in the construction of C-sp(2)-C-sp(3) bonds.

引用

页码：3128 / 3136

页数：9

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