The immunological synapse: a focal point for endocytosis and exocytosis

被引：166

作者：

Griffiths, Gillian M. ^{[1
]}

Tsun, Andy ^{[1
]}

Stinchcombe, Jane C. ^{[1
]}

机构：

[1] Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 0XY, England

来源：

JOURNAL OF CELL BIOLOGY | 2010年 / 189卷 / 03期

基金：

英国惠康基金;

关键词：

CYTOTOXIC T-LYMPHOCYTES; MICROTUBULE-ORGANIZING CENTER; CELL-RECEPTOR MICROCLUSTERS; PRESENTING B-CELLS; INTRAFLAGELLAR TRANSPORT; GRANULE EXOCYTOSIS; PRIMARY CILIUM; MEDIATED CYTOTOXICITY; CULTURED FIBROBLASTS; TRYPANOSOMA-BRUCEI;

D O I：

10.1083/jcb.201002027

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There are many different cells in the immune system. To mount an effective immune response, they need to communicate with each other. One way in which this is done is by the formation of immunological synapses between cells. Recent developments show that the immune synapse serves as a focal point for exocytosis and endocytosis, directed by centrosomal docking at the plasma membrane. In this respect, formation of the immunological synapse bears striking similarities to cilia formation and cytokinesis. These intriguing observations suggest that the centrosome may play a conserved role in designating a specialized area of membrane for localized endocytosis and exocytosis.

引用

页码：397 / 406

页数：8

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