Emerging landscape of circular RNAs in lung cancer

被引：98

作者：

Hu, Wei ^{[1
]}

Bi, Zhuo-Yue ^{[2
]}

Chen, Zhen-Long ^{[3
]}

Liu, Cong ^{[1
]}

Li, Lin-Lin ^{[1
]}

Zhang, Feng ^{[1
]}

Zhou, Qun ^{[1
]}

Zhu, Wei ^{[1
]}

Song, Yang-Yi-Yan ^{[1
]}

Zhan, Bo-Tao ^{[4
]}

Zhang, Qian ^{[5
]}

Bi, Yong-Yi ^{[1
]}

Sun, Cheng-Cao ^{[1
,6
]}

Li, De-Jia ^{[1
]}

机构：

[1] Wuhan Univ, Sch Hlth Sci, Dept Prevent Med, 115 Donghu Rd, Wuhan 430071, Hubei, Peoples R China

[2] Hubei Prov Acad Prevent Med, Hubei Prov Key Lab Appl Toxicol, Wuhan 430079, Hubei, Peoples R China

[3] Wuhan Hosp Prevent & Treatment Occupat Dis, Wuhan 430015, Hubei, Peoples R China

[4] Hubei Univ Arts & Sci, Affiliated Hosp, Xiangyang Cent Hosp, Xiangyang 441021, Hubei, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Pathol, Wuhan 430014, Hubei, Peoples R China

[6] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2018年 / 427卷

基金：

中国博士后科学基金;

关键词：

Circular RNA; Back-splicing; MicroRNA sponge; Lung cancer; Biomarker; EPITHELIAL-MESENCHYMAL TRANSITION; ANAPLASTIC LYMPHOMA KINASE; NONCODING RNAS; NEVER SMOKERS; APOPTOSIS; GROWTH; ROLES; PROGRESSION; BIOGENESIS; INHIBITION;

D O I：

10.1016/j.canlet.2018.04.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer, the leading cause of cancer deaths worldwide, is characterized with malignant cell growth. Advances in next-generation sequencing has helped us further understand RNA and identify novel circular RNAs (circRNAs) that may be useful in the early diagnosis and treatment of lung cancer. Similar to other noncoding RNAs, circRNAs present diverse biological functions in normal and disease states, including various types of cancers. This review focuses mainly on the poorly understood functions of circRNA in lung cancer. This paper also summarizes the recent advances in circRNA biogenesis, analyzes the role of circRNAs in cancers, and discusses the potential mechanisms of circRNAs in lung cancer. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：18 / 27

页数：10

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