Human Germline Cell Development: from the Perspective of Single-Cell Sequencing

被引：49

作者：

Wen, Lu ^{[1
]}

Tang, Fuchou ^{[1
]}

机构：

[1] Peking Univ, Coll Life Sci, Biomed Pioneering Innovat Ctr BIOPIC, Beijing Adv Innovat Ctr Genom ICG, Beijing 100871, Peoples R China

来源：

MOLECULAR CELL | 2019年 / 76卷 / 02期

关键词：

MOUSE EARLY EMBRYOS; DNA METHYLATION; SELF-ORGANIZATION; GENOME-WIDE; CHROMATIN; SEQ; SPERMATOGENESIS; TRANSCRIPTOME; LANDSCAPE; DYNAMICS;

D O I：

10.1016/j.molcel.2019.08.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Germline cells are the beginning of new individuals in multicellular animals, including humans. Our understanding of these cell types is limited by the difficulty of analyzing the precious and heterogeneous germline tissue samples. The rapid development of single-cell sequencing technologies provides a chance for comprehensive profiling of the omics dynamics of human germline development. In this review, we discuss progress in analyzing the development of human germline cells, including preimplantation and implantation embryos, fetal germ cells (FGCs), and adult spermatogenesis by single-cell transcriptome and epigenome sequencing technologies.

引用

页码：320 / 328

页数：9

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