Lactadherin: From a Well-Known Breast Tumor Marker to a Possible Player in Extracellular Vesicle-Mediated Cancer Progression

被引:10
作者
Duran-Jara, Eduardo [1 ]
Vera-Tobar, Tamara [1 ]
De Lourdes Lobos-Gonzalez, Lorena [1 ,2 ]
机构
[1] Univ Desarrollo, Fac Med, Ctr Med Regenerat, Inst Ciencias & Innovac Med,Clin Alemana, Santiago 7710162, Chile
[2] Adv Ctr Chron Dis ACCDiS, Santiago 8380000, Chile
关键词
lactadherin; breast cancer; metastasis; extracellular vesicles; exosomes; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR; 8; HUMAN-MILK; MONOCLONAL-ANTIBODIES; FACTOR-VIII; MEMBRANE-VESICLES; MFG-E8; EXOSOMES; ANTIGENS; EXPRESSION;
D O I
10.3390/ijms23073855
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lactadherin is a secreted glycoprotein associated with the milk fat globule membrane, which is highly present in the blood and in the mammary tissue of lactating women. Several biological functions have been associated with this protein, mainly attributable to its immunomodulatory role promoting phagocyte-mediated clearance of apoptotic cells. It has been shown that lactadherin also plays important roles in cell adhesion, the promotion of angiogenesis, and tissue regeneration. On the other hand, this protein has been used as a marker of breast cancer and tumor progression. Recently, high levels of lactadherin has been associated with poor prognosis and decreased survival, not only in breast cancer, but also in melanoma, ovarian, colorectal, and other types of cancer. Although the mechanisms responsible for the tumor-promoting effects attributed to lactadherin have not been fully elucidated, a growing body of literature indicates that lactadherin could be a promising therapeutic target and/or biomarker for breast and other tumors. Moreover, recent studies have shown its presence in extracellular vesicles derived from cancer cell lines and cancer patients, which was associated with cancer aggressiveness and worse prognosis. Thus, this review will focus on the link between lactadherin and cancer development and progression, its possible use as a cancer biomarker and/or therapeutic target, concluding with a possible role of this protein in cellular communication mediated by extracellular vesicles
引用
收藏
页数:17
相关论文
共 93 条
[1]   Functional analyses of two cellular binding domains of bovine lactadherin [J].
Andersen, MH ;
Graversen, H ;
Fedosov, SN ;
Petersen, TE ;
Rasmussen, JT .
BIOCHEMISTRY, 2000, 39 (20) :6200-6206
[2]   DIFFERENTIATION ANTIGENS EXPRESSED BY EPITHELIAL-CELLS IN THE LACTATING BREAST ARE ALSO DETECTABLE IN BREAST CANCERS [J].
ARKLIE, J ;
TAYLORPAPADIMITRIOU, J ;
BODMER, W ;
EGAN, M ;
MILLIS, R .
INTERNATIONAL JOURNAL OF CANCER, 1981, 28 (01) :23-29
[3]   Milk fat globule epidermal growth factor 8 (MFG-E8): A novel protein in the mammalian endometrium with putative roles in implantation and placentation [J].
Bocca, S. M. ;
Anderson, S. ;
Amaker, B. ;
Swanson, R. J. ;
Franchi, A. ;
Lattanzio, E. ;
Oehninger, S. .
PLACENTA, 2012, 33 (10) :795-802
[4]   Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines [J].
Campos, America ;
Salomon, Carlos ;
Bustos, Rocio ;
Diaz, Jorge ;
Martinez, Samuel ;
Silva, Veronica ;
Reyes, Constanza ;
Diaz-Valdivia, Natalia ;
Varas-Godoy, Manuel ;
Lobos-Gonzalez, Lorena ;
Quest, Andrew F. G. .
NANOMEDICINE, 2018, 13 (20) :2597-2609
[5]   Coptisine suppresses tumor growth and progression by down-regulating MFG-E8 in colorectal cancer [J].
Cao, Qianyu ;
Hong, Shengwei ;
Li, Yuanyuan ;
Chen, Heng ;
Shen, Yining ;
Shao, Kang ;
Lu, Mengjie ;
Dai, Hui ;
Ma, Shitang ;
Dai, Guoliang .
RSC ADVANCES, 2018, 8 (54) :30937-30945
[6]   MFG-E8/lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells [J].
Carrascosa, C. ;
Obula, R. G. ;
Missiaglia, E. ;
Lehr, H-A ;
Delorenzi, M. ;
Frattini, M. ;
Rueegg, C. ;
Mariotti, A. .
ONCOGENE, 2012, 31 (12) :1521-1532
[7]   CIRCULATING HUMAN MAMMARY EPITHELIAL ANTIGENS IN BREAST-CANCER [J].
CERIANI, RL ;
SASAKI, M ;
SUSSMAN, H ;
WARA, WM ;
BLANK, EW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (17) :5420-5424
[8]  
CERIANI RL, 1987, CANCER RES, V47, P532
[9]  
CERIANI RL, 1986, MECHANISMS CANCER ME, P235
[10]   Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells [J].
Cho, Jung Ah ;
Park, Ho ;
Lim, Eun Hye ;
Lee, Kyo Won .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2012, 40 (01) :130-138