The Cardiovascular Burden in End-Stage Renal Disease

被引：56

作者：

Cozzolino, Mario ^{[1
]}

Galassi, Andrea ^{[1
]}

Pivari, Francesca ^{[1
]}

Ciceri, Paola ^{[1
]}

Conte, Ferruccio ^{[1
]}

机构：

[1] Univ Milan, San Paolo Hosp, ASST Santi Paolo & Carlo, Dept Hlth Sci,Renal Div, Milan, Italy

来源：

EXPANDED HEMODIALYSIS: INNOVATIVE CLINICAL APPROACH IN DIALYSIS | 2017年 / 191卷

关键词：

CHRONIC KIDNEY-DISEASE; UREMIC TOXINS; SERUM PHOSPHATE; MORTALITY RISK; FGF23; ATHEROSCLEROSIS; ALBUMINURIA; POPULATION; PHOSPHORUS; EXPRESSION;

D O I：

10.1159/000479250

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

It is well documented that chronic kidney disease patients have an extremely high risk of developing cardiovascular (CV) disease (CVD) compared to the general population. Declining renal function itself represents a continuum of CV risk, and in those individuals who survive to reach end-stage renal disease, the risk of suffering a cardiac event is uncomfortably and unacceptably high. Several pathophysiological pathways have been suggested to account for this, including endothelial dysfunction, dyslipidemia, inflammation, left ventricular hypertrophy, troponins, phosphate, vitamin D, fibroblast growth factor-23, and NT-proBNP. All these conditions and biomarkers may have clear associations with current and subsequent CVD. (c) 2017 S. Karger AG, Basel

引用

页码：44 / 57

页数：14

共 47 条

[1] Gut microbiome and kidney disease: a bidirectional relationship
Al Khodor, Souhaila
Shatat, Ibrahim F.
[J]. PEDIATRIC NEPHROLOGY, 2017, 32 (06) : 921 - 931
[2] FGF23 regulates renal sodium handling and blood pressure
Andrukhova, Olena
Slavic, Svetlana
Smorodchenko, Alina
Zeitz, Ute
Shalhoub, Victoria
Lanske, Beate
Pohl, Elena E.
Erben, Reinhold G.
[J]. EMBO MOLECULAR MEDICINE, 2014, 6 (06) : 744 - 759
[3] [Anonymous], 2016, USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States
[4] Fibroblast growth factor 23 (FGF23) and mortality: The Ludwigshafen Risk and Cardiovascular Health Study
Brandenburg, Vincent M.
Kleber, Marcus E.
Vervloet, Marc G.
Tomaschitz, Andreas
Pilz, Stefan
Stojakovic, Tatjana
Delgado, Graciela
Grammer, Tanja B.
Marx, Nikolaus
Maerz, Winfried
Scharnagl, Hubert
[J]. ATHEROSCLEROSIS, 2014, 237 (01) : 53 - 59
[5] Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells
Chen, NX
O'Neill, KD
Duan, D
Moe, SM
[J]. KIDNEY INTERNATIONAL, 2002, 62 (05) : 1724 - 1731
[6] Sevelamer Versus Calcium Carbonate in Incident Hemodialysis Patients: Results of an Open-Label 24-Month Randomized Clinical Trial
Di Iorio, Biagio
Molony, Donald
Bell, Cynthia
Cucciniello, Emanuele
Bellizzi, Vincenzo
Russo, Domenico
Bellasi, Antonio
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2013, 62 (04) : 771 - 778
[7] Normalization of hemoglobin level in patients with chronic kidney disease and anemia
Drueke, Tilman B.
Locatelli, Francesco
Clyne, Naomi
Eckardt, Kai-Uwe
Macdougall, Iain C.
Tsakiris, Dimitrios
Burger, Hans-Ulrich
Scherhag, Armin
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (20) : 2071 - 2084
[8] Effect of dialysis dose and membrane flux in maintenance hemodialysis.
Eknoyan, G
Beck, GJ
Cheung, AK
Daugirdas, JT
Greene, T
Kusek, JW
Allon, M
Bailey, J
Delmez, JA
Depner, TA
Dwyer, JT
Levey, AS
Levin, NW
Milford, E
Ornt, DB
Rocco, MV
Schulman, G
Schwab, SJ
Teehan, BP
Toto, R
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (25) : 2010 - 2019
[9] FGF23 induces left ventricular hypertrophy
Faul, Christian
Amaral, Ansel P.
Oskouei, Behzad
Hu, Ming-Chang
Sloan, Alexis
Isakova, Tamara
Gutierrez, Orlando M.
Aguillon-Prada, Robier
Lincoln, Joy
Hare, Joshua M.
Mundel, Peter
Morales, Azorides
Scialla, Julia
Fischer, Michael
Soliman, Elsayed Z.
Chen, Jing
Go, Alan S.
Rosas, Sylvia E.
Nessel, Lisa
Townsend, Raymond R.
Feldman, Harold I.
Sutton, Martin St. John
Ojo, Akinlolu
Gadegbeku, Crystal
Di Marco, Giovana Seno
Reuter, Stefan
Kentrup, Dominik
Tiemann, Klaus
Brand, Marcus
Hill, Joseph A.
Moe, Orson W.
Kuro-o, Makoto
Kusek, John W.
Keane, Martin G.
Wolf, Myles
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (11) : 4393 - 4408
[10] Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States medicare population, 1998 to 1999
Foley, RN
Murray, AM
Li, SL
Herzog, CA
McBean, AM
Eggers, PW
Collins, AJ
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (02): : 489 - 495

← 1 2 3 4 5 →