Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-κB activity

被引：78

作者：

Yip, KHM

Zheng, MH

Feng, HT

Steer, JH

Joyce, DA

Xu, JK ^{[1
]}

机构：

[1] Univ Western Australia, Sch Surg & Pathol, Mol Orthopaed Lab, Nedlands, WA 6009, Australia

[2] Univ Western Australia, Sch Med & Pharmacol, Western Australia Med Res Inst, Pharmacol Unit, Nedlands, WA 6009, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期

关键词：

osteoclast; RANKL; osteolysis; lipopolysaccharide; parthenolide; NF-kappa B;

D O I：

10.1359/JBMR.040919

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Effective treatment for bacteria-induced bone lytic diseases is not yet available. In this study, we showed that PAR, an NF-B-kappa inhibitor found in medicinal herbs, can block LPS-induced osteolysis. PAR does this by inhibiting osteoclastogenesis and bone resorption and promoting apoptosis of osteoclasts through the suppression of NF-B-K activity.

引用

收藏

页码：1905 / 1916

页数：12

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