Illicaborins A-C, three prenylated C6-C3 compounds from the fruits of Illicium arborescens

被引：10

作者：

Lin, Ya-Xu ^{[1
]}

Fazary, Ahmed Eid ^{[1
]}

Chen, Shun-Ying ^{[2
]}

Chien, Ching-Te ^{[2
]}

Kuo, Yao-Haur ^{[3
]}

Sheu, Shiow-Yunn ^{[4
]}

Shen, Ya-Ching ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 100, Taiwan

[2] Taiwan Forestry Res Inst, Div Silviculture, Taipei, Taiwan

[3] Natl Res Inst Chinese Med, Taipei, Taiwan

[4] Taipei Med Univ, Sch Pharm, Taipei, Taiwan

来源：

FOOD CHEMISTRY | 2010年 / 123卷 / 04期

关键词：

Illicium arborescens; Illicaborins; Cytotoxic activities; PHYTOQUINOIDS; PLANTS; CONSTITUENTS; NEOLIGNANS;

D O I：

10.1016/j.foodchem.2010.05.069

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new prenylated C-6-C-3 compounds, illicaborins A-C (1-3), were isolated and characterised from the fruits of Illicium arborescens Hayata. Their structures were determined by extensive spectroscopic analyses (UV, CD, IR, H-1 NMR, C-13 NMR, H-1-H-1 COSY, HMQC, HMBC, and NOESY) including molecular modelling. Compound 1 possesses a new carbon skeleton having a prenylated C-6-C-3 skeleton with an additional CH2OH group at the C-2 position. The cytotoxic activities of compounds 1-3 were tested and evaluated against Hep-2, Daoy, MCF-7 and WiDr tumour cell lines. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1105 / 1111

页数：7

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