Clinical trial enrollment of adolescents and young adults with sarcoma

被引：31

作者：

Davis, Lara E. ^{[1
,2
]}

Janeway, Katherine A. ^{[3
]}

Weiss, Aaron R. ^{[4
]}

Chen, Yen-Lin E. ^{[5
]}

Scharschmidt, Thomas J. ^{[6
]}

Krailo, Mark ^{[7
]}

Bender, Julia L. Glade ^{[8
]}

Kopp, Lisa M. ^{[9
]}

Patel, Shreyaskumar R. ^{[10
]}

Schwartz, Gary K. ^{[11
]}

Horvath, L. Elise ^{[12
,17
]}

Hawkins, Douglas S. ^{[13
]}

Chuk, Meredith K. ^{[14
]}

Reinke, Denise K. ^{[15
]}

Gorlick, Richard G. ^{[10
]}

Randall, R. Lor ^{[16
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Med, Knight Canc Inst, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Dept Pediat, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA

[3] Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA USA

[4] Maine Childrens Canc Program, Scarborough, ME USA

[5] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA

[6] Ohio State Univ, Dept Orthopaed, Columbus, OH 43210 USA

[7] Univ Southern Calif, Dept Preventat Med, Los Angeles, CA USA

[8] Columbia Univ, Dept Pediat, Med Ctr, New York, NY 10027 USA

[9] Univ Arizona, Dept Pediat, Ctr Canc, Tucson, AZ 85721 USA

[10] Univ Texas MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX 77030 USA

[11] Columbia Univ, Dept Med, Med Ctr, New York, NY USA

[12] Astellas Pharma, Naperville, IL USA

[13] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle Childrens Hosp, Seattle, WA 98195 USA

[14] US FDA, Silver Spring, MD USA

[15] Sarcoma Alliance Res Collaborat, Ann Arbor, MI USA

[16] Univ Utah, Dept Orthoped, Huntsman Canc Inst, Salt Lake City, UT USA

[17] Alliance Clin Trials Oncol, Chicago, IL USA

来源：

CANCER | 2017年 / 123卷 / 18期

关键词：

adolescent; clinical trials; National Clinical Trials Network; sarcoma; young adult; CHILDRENS ONCOLOGY; CANCER; SURVIVAL; CHEMOTHERAPY; TRENDS;

D O I：

10.1002/cncr.30757

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

More than half of all sarcomas occur in adolescents and young adults (AYAs) aged 15 to 39 years. After the publication of the AYA series in the April 1, 2016 issue of Cancer, several leaders in the field of sarcoma across disciplines gathered to discuss the status of sarcoma clinical research in AYAs. They determined that a focused effort to include the underrepresented and understudied AYA population in current and future sarcoma clinical trials is overdue. Trial enrichment for AYA-aged sarcoma patients will produce more meaningful results that better represent the disease's biology, epidemiology, and treatment environment. To address the current deficit, this commentary outlines changes believed to be necessary to expediently achieve an increase in the enrollment of AYAs in sarcoma clinical trials. Cancer 2017;123:3434-40. (c) 2017 American Cancer Society.

引用

页码：3434 / 3440

页数：7

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