Gold-Catalyzed Highly Diastereoselective Oxy-Propargylamination of Allenamides with C-Alkynyl N-Boc N,O-Acetals

被引：24

作者：

Chen, Long ^{[1
]}

Yu, Jianliang ^{[1
]}

Tang, Shengbiao ^{[1
]}

Shao, Ying ^{[1
]}

Sun, Jiangtao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 22期

基金：

中国国家自然科学基金;

关键词：

NUCLEOPHILIC-ADDITION; 2+2 CYCLOADDITION; ALLENYL AMIDES; ACCESS; ENAMIDES; INDOLES;

D O I：

10.1021/acs.orglett.9b03449

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A gold-catalyzed oxy-propargylamination of N-allenamides has been developed by using C-alkynyl N-Bocacetals as the difunctionalization reagents. Typically, this process features the unique proximal addition rather than the common distal nucleophilic addition for gold(I)-activated allenamides. This reaction is atom-economic and provides highly functionalized 1,3-amino alcohol derivatives in good yields with good to excellent diastereoselectivities under mild reaction conditions.

引用

页码：9050 / 9054

页数：5

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