Clinical immunologic approaches for the treatment of Alzheimer's disease

被引:23
|
作者
Solomon, Beka [1 ]
机构
[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel
关键词
beta-amyloid; active immunization; Alzheimer's disease; cognitive functions; immunotherapy; passive immunization; site-directed antibodies;
D O I
10.1517/13543784.16.6.819
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent clinical trials of active vaccination against beta-amyloid (A beta) have succeeded in clearing A beta plaques; however, further understanding of immunization with regards to inflammation and other hallmarks of Alzheimer's disease pathology is required. Antibodies generated with this first-generation vaccine may not have had the desired therapeutic properties or targeted the 'correct' mechanism, but they have opened the way for new clinical approaches, which are now under consideration. Passive administration of monoclonal antibodies directed to various regions of A beta peptide and/or administration of immunoconjugates of only small fragments of the N-terminal region may lead to the development of an improved second generation of A beta vaccines. Amyloid immunotherapy offers genuine opportunities for disease treatment; however, such an approach towards treating and preventing Alzheimer's disease patients requires careful antigen and antibody selection to maximize efficacy and minimize adverse events.
引用
收藏
页码:819 / 828
页数:10
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