Clinical immunologic approaches for the treatment of Alzheimer's disease
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作者:
Solomon, Beka
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Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel
Solomon, Beka
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[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel
Recent clinical trials of active vaccination against beta-amyloid (A beta) have succeeded in clearing A beta plaques; however, further understanding of immunization with regards to inflammation and other hallmarks of Alzheimer's disease pathology is required. Antibodies generated with this first-generation vaccine may not have had the desired therapeutic properties or targeted the 'correct' mechanism, but they have opened the way for new clinical approaches, which are now under consideration. Passive administration of monoclonal antibodies directed to various regions of A beta peptide and/or administration of immunoconjugates of only small fragments of the N-terminal region may lead to the development of an improved second generation of A beta vaccines. Amyloid immunotherapy offers genuine opportunities for disease treatment; however, such an approach towards treating and preventing Alzheimer's disease patients requires careful antigen and antibody selection to maximize efficacy and minimize adverse events.
机构:
Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USAUniv Maryland, Dept Neurol, Baltimore, MD 21201 USA
Lee, Hyoung-Gon
Zhu Xiongwei
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Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USAUniv Maryland, Dept Neurol, Baltimore, MD 21201 USA
Zhu Xiongwei
Perry, George
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Univ Texas San Antonio, Coll Sci, San Antonio, TX USA
Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USAUniv Maryland, Dept Neurol, Baltimore, MD 21201 USA
Perry, George
Smith, Mark A.
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Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USAUniv Maryland, Dept Neurol, Baltimore, MD 21201 USA
Smith, Mark A.
Castellani, Rudy J.
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机构:
Univ Maryland, Div Neuropathol, Dept Pathol, Baltimore, MD 21201 USAUniv Maryland, Dept Neurol, Baltimore, MD 21201 USA
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Case Western Reserve Univ, Cleveland, OH 44106 USAUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Lee, Hyun Pil
Zhu, Xiongwei
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Case Western Reserve Univ, Cleveland, OH 44106 USAUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Zhu, Xiongwei
Casadesus, Gemma
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Case Western Reserve Univ, Cleveland, OH 44106 USAUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Casadesus, Gemma
Castellani, Rudy J.
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Univ Maryland, College Pk, MD 20742 USAUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Castellani, Rudy J.
Nunomura, Akihiko
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Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Yamanashi, JapanUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Nunomura, Akihiko
Smith, Mark A.
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Case Western Reserve Univ, Cleveland, OH 44106 USAUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Smith, Mark A.
Lee, Hyoung-gon
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Case Western Reserve Univ, Cleveland, OH 44106 USAUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Lee, Hyoung-gon
Perry, George
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机构:
Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
Case Western Reserve Univ, Cleveland, OH 44106 USAUniv Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
机构:
Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci, IL-69978 Tel Aviv, IsraelTel Aviv Univ, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci, IL-69978 Tel Aviv, Israel