Changes of tear film lipid layer thickness by 3% diquafosol ophthalmic solutions in patients with dry eye syndrome

被引：9

作者：

Kang, Dong-Hyun ^{[1
]}

Lee, Yong-Woo ^{[1
]}

Hwang, Kyu-Yeon ^{[1
]}

Koh, Kyung-Min ^{[1
]}

Kwon, Young-A ^{[1
]}

Kim, Byung-Yeop ^{[1
]}

Song, Sang-Wroul ^{[1
]}

Kim, Kook-Young ^{[1
]}

机构：

[1] Konyang Univ, Kims Eye Hosp, Myung Gok Eye Res Inst, Dept Ophthalmol,Coll Med, Seoul 150034, South Korea

来源：

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2019年 / 12卷 / 10期

关键词：

diquafosol ophthalmic solutions; dry eye syndrome; tear film lipid layer thickness; MEIBOMIAN GLAND DYSFUNCTION; P2Y(2) RECEPTOR; SECRETION; RABBIT; INS365; GLYCOPROTEIN; DEFINITION; EXPRESSION; INCREASES; EFFICACY;

D O I：

10.18240/ijo.2019.10.06

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

AIM: To evaluate the quantitatively changes in lipid layer thickness (LLT) when 3% diquafosol eye drop is used for dry eye patients using the tear film interferometer. METHODS: A total 124 participants (32 males, 92 females; mean age, 28.9y) diagnosed with dry eye disease (DED) received topical instillation of 4 ophthalmic solutions in one eye: diquafosol, normal saline, 0.1% sodium hyaluronate and 0.3% gatifloxacin, in a masked manner. LLT was measured using an interferometer at baseline and 20min after the instillation of each ophthalmic solutions. RESULTS: Changes of LLT after instillation (nm, mean +/- standard error) were as follows: 12.6 +/- 2.0 for diquafosol (P<0.001), 1.2 +/- 2.2 for normal saline (P=0.301), 1.5 +/- 2.0 for hyaluronate (P=0.495), and 0.5 +/- 3.2 for gatifloxacin (P=0.884). CONCLUSION: Topical instillation of diquafosol increases tear film LLT in DED patients. Diquafosol 3% eye drop might be effective treatment option of evaporative DED with meibomian gland dysfunction.

引用

页码：1555 / 1560

页数：6

共 36 条

[1] Topical diquafosol for patients with obstructive meibomian gland dysfunction [J].