Models for measuring anthelmintic drug efficacy for parasitologists

被引：19

作者：

Walker, Martin ^{[1
]}

Churcher, Thomas S. ^{[1
]}

Basanez, Maria-Gloria ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, London Ctr Neglected Trop Dis Res,Dept Infect Dis, London W2 1PG, England

来源：

TRENDS IN PARASITOLOGY | 2014年 / 30卷 / 11期

基金：

英国医学研究理事会;

关键词：

marginal models; mixed models; mass drug administration; longitudinal data; hookworm; albendazole; COUNT REDUCTION TEST; FECAL EGG COUNTS; SOIL-TRANSMITTED HELMINTHS; LONGITUDINAL DATA-ANALYSIS; LINEAR MIXED MODELS; SCHISTOSOMA-MANSONI; STRONGYLE PARASITES; TRICHURIS-TRICHIURA; HOOKWORM INFECTION; RESISTANCE;

D O I：

10.1016/j.pt.2014.08.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Anthelmintic drug efficacy (ADE) is generally estimated as a population average effect, despite drug responses varying among individuals according to a variety of measurable and non-measurable factors. Model-based and/or individual-level analyses are scarce and often methodologically frail. We propose that wider application of marginal and mixed models would offer benefits to the evaluation of ADE. We demonstrate, with a worked example, how model-based analyses: (i) capture the effects of correlation among hierarchically structured longitudinal data on estimates of ADE; (ii) permit robust inference on the association of measurable factors with ADE; and WO enable estimation of variation among individual-level estimates of ADE. The application of modelling approaches is discussed in the context of mass drug administration-based control of human helminthiases.

引用

页码：528 / 537

页数：10

共 89 条

[1] Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control [J].