Search for morbillivirus proteins in multiple sclerosis brain tissue

被引：11
作者：
Geeraedts, F
Wilczak, N
van Binnendijk, R
De Keyser, J
机构：
[1] Acad Ziekenhuis Groningen, Dept Neurol, NL-9700 RB Groningen, Netherlands
[2] Rijksinst Volksgezondheid Milieu, NL-3720 BA Bilthoven, Netherlands
来源：
NEUROREPORT | 2004年 / 15卷 / 01期
关键词：
astrocytes; canine distemper virus; immunohistochemistry; measles virus; morbillivirus; multiple sclerosis;
D O I：
10.1097/00001756-200401190-00007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated brain samples of patients with multiple sclerosis (MS) and controls with immunohistochemistry using monoclonal antibodies (MoAbs) against canine distemper virus (CDV) and measles virus (MV) proteins. All stained negative except for MoAb F3-5, which recognises a conserved epitope on the fusion protein of morbilliviruses. F3-5 immunostaining was found in 8/9 MS plaques and 2/5 herpes simplex virus encephalitis brain samples, but not in six controls or four patients with ischaemic stroke. Using RTPCR we found no evidence for the presence of MV in MS plaques. The F3-5 epitope may represent a protein that is upregulated during inflammation or point to a yet unrecognised morbillivirus in the human central nervous system that might be implicated in MS pathogenesis.
引用
收藏
页码：27 / 32
页数：6
相关论文
共 25 条
[1]   RESTRICTED EXPRESSION OF VIRAL SURFACE-PROTEINS IN CANINE-DISTEMPER ENCEPHALITIS [J].
ALLDINGER, S ;
BAUMGARTNER, W ;
ORVELL, C .
ACTA NEUROPATHOLOGICA, 1993, 85 (06) :635-645
[2]   CANINE-DISTEMPER VIRUS CLEARANCE IN CHRONIC INFLAMMATORY DEMYELINATION [J].
BOLLO, E ;
ZURBRIGGEN, A ;
VANDEVELDE, M ;
FANKHAUSER, R .
ACTA NEUROPATHOLOGICA, 1986, 72 (01) :69-73
[3]   POTENTIAL ROLE OF PARAMYXOVIRUSES IN MULTIPLE-SCLEROSIS [J].
COOK, SD ;
BLUMBERG, B ;
DOWLING, PC .
NEUROLOGIC CLINICS, 1986, 4 (01) :303-319
[4]   EXAMINATION OF 8 CASES OF MULTIPLE-SCLEROSIS AND 56 NEUROLOGICAL AND NON-NEUROLOGICAL CONTROLS FOR GENOMIC SEQUENCES OF MEASLES-VIRUS, CANINE-DISTEMPER VIRUS, SIMIAN VIRUS-5 AND RUBELLA-VIRUS [J].
COSBY, SL ;
MCQUAID, S ;
TAYLOR, MJ ;
BAILEY, M ;
RIMA, BK ;
MARTIN, SJ ;
ALLEN, IV .
JOURNAL OF GENERAL VIROLOGY, 1989, 70 :2027-2036
[5]   Astrocytes in multiple sclerosis lack beta-2 adrenergic receptors [J].
De Keyser, J ;
Wilczak, N ;
Leta, R ;
Streetland, C .
NEUROLOGY, 1999, 53 (08) :1628-1633
[6]   Disappearance of β2-adrenergic receptors on astrocytes in canine distemper encephalitis:: possible implications for the pathogenesis of multiple sclerosis [J].
De Keyser, J ;
Wilczak, N ;
Walter, JH ;
Zurbriggen, A .
NEUROREPORT, 2001, 12 (02) :191-194
[7]  
de Vries P, 1987, Viral Immunol, V1, P25, DOI 10.1089/vim.1987.1.25
[8]   MEASLES-VIRUS FUSION PROTEIN PRESENTED IN AN IMMUNE-STIMULATING COMPLEX (ISCOM) INDUCES HEMOLYSIS-INHIBITING AND FUSION-INHIBITING ANTIBODIES, VIRUS-SPECIFIC T-CELLS AND PROTECTION IN MICE [J].
DEVRIES, P ;
VANBINNENDIJK, RS ;
VANDERMAREL, P ;
VANWEZEL, AL ;
VOORMA, HO ;
SUNDQUIST, B ;
UYTDEHAAG, FGCM ;
OSTERHAUS, ADME .
JOURNAL OF GENERAL VIROLOGY, 1988, 69 :549-559
[9]  
DEVRIES P, 1989, VACC 90 P M MOD APPR, P139
[10]   MEASLES-VIRUS NUCLEIC-ACID SEQUENCES IN HUMAN-BRAIN [J].
DOWLING, PC ;
BLUMBERG, BM ;
KOLAKOFSKY, D ;
COOK, P ;
JOTKOWITZ, A ;
PRINEAS, JW ;
COOK, SD .
VIRUS RESEARCH, 1986, 5 (01) :97-107
123