WNT4 is expressed in human fetal and adult ovaries and its signaling contributes to ovarian cell survival

被引：36

作者：

Jaaskelainen, Minna ^{[1
,2
]}

Prunskaite-Hyyrylainen, Renata ^{[3
,4
]}

Naillat, Florence ^{[3
,4
]}

Parviainen, Helka ^{[6
,7
,8
]}

Anttonen, Mikko ^{[7
,8
]}

Heikinheimo, Markku ^{[6
,11
]}

Liakka, Annikki ^{[5
]}

Ola, Roxana ^{[9
,10
]}

Vainio, Seppo ^{[3
,4
]}

Vaskivuo, Tommi E. ^{[2
]}

Tapanainen, Juha S. ^{[1
,2
]}

机构：

[1] Oulu Univ Hosp, Dept Obstet & Gynecol, Oulu, Finland

[2] Oulu Univ Hosp, Clin Res Ctr, Oulu, Finland

[3] Univ Oulu, Dev Biol Lab, Bioctr Oulu, Oulu Ctr Cell Matrix Res, Oulu 90014, Finland

[4] Univ Oulu, Inst Biomed, Dept Med Biochem & Mol Biol, Oulu 90014, Finland

[5] Univ Oulu, Dept Pathol, Oulu 90014, Finland

[6] Univ Helsinki, Childrens Hosp, FIN-00014 Helsinki, Finland

[7] Univ Helsinki, Program Womens Hlth, FIN-00014 Helsinki, Finland

[8] Univ Helsinki, Dept Obstet & Gynecol, FIN-00014 Helsinki, Finland

[9] Univ Helsinki, Dept Biochem, FIN-00014 Helsinki, Finland

[10] Univ Helsinki, Inst Biomed, Dev Biol Grp, FIN-00014 Helsinki, Finland

[11] Washington Univ, Dept Pediat, St Louis, MO 63130 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 317卷 / 1-2期

基金：

芬兰科学院;

关键词：

WNT4; Apoptosis; Oocyte; Granulosa cell; Human ovary; MALE SEX REVERSAL; MOUSE OVARY; APOPTOSIS; GATA-4; DEFICIENCY; MUTATION; PATHWAY; LIFE;

D O I：

10.1016/j.mce.2009.11.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

WNT4 plays an important role in female sexual development and ovarian function. WNT4-deficiency leads disturbed development of the internal genitalia in mouse and human, and to a dramatic reduction of mouse oocytes. However, the expression and role of WNT4 in human ovaries is yet unknown. The expression of WNT4 mRNA and protein was studied in human adult and fetal ovaries (gestational ages 12-41 weeks), and the role of WNT4 in oocyte apoptosis was investigated in WNT4-deficient mice. WNT4 mRNA and protein were present in human ovaries throughout fetal development and in different follicular stages in adult ovaries. Compared with wild-type mice, WNT4-deficient mice had a markedly enhanced rate of oocyte apoptosis, with the highest values at gestational ages of 14.5 and 16.5 days Post-coitum. The current results Support a view that WNT4 may have a role in oocyte selection and follicle formation and maturation in human ovaries. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：106 / 111

页数：6

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