Nociceptin hyperpolarises neurones in the rat ventromedial hypothalamus

被引：29

作者：

Lee, K ^{[1
]}

Nicholson, JR ^{[1
]}

McKnight, AT ^{[1
]}

机构：

[1] Univ Cambridge, Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England

来源：

NEUROSCIENCE LETTERS | 1997年 / 239卷 / 01期

关键词：

whole-cell patch clamp; nociceptin; ventromedial hypothalamus; ORL1; receptor;

D O I：

10.1016/S0304-3940(97)00875-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Patch-clamp recording techniques were used to examine the effect of nociceptin upon neurones contained in slices from the rat ventromedial hypothalamus (VMH). Bath application of 50-300 nM nociceptin hyperpolarised neurones in a concentration-dependent manner that was not affected by either tetrodotoxin (TTX) or naloxone. In voltage-clamp studies nociceptin induced an outward current at -60mV that had a reversal potential of -100.2 +/- 4.6 mV and was abolished by bath application of 2 mM BaCl2. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：37 / 40

页数：4

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