Cu-Catalyzed Arylation of Phenols: Synthesis of Sterically Hindered and Heteroaryl Diaryl Ethers

被引：175
作者：
Maiti, Debabrata [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 05期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
CROSS-COUPLING REACTIONS; ARYL IODIDES; NUCLEOPHILIC-SUBSTITUTION; CUPRIC ACETATE; BOND FORMATION; O BOND; COPPER; HALIDES; LIGAND; EFFICIENT;
D O I：
10.1021/jo9026935
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K3PO4 with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.
引用
收藏
页码：1791 / 1794
页数：4
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