Oblongolides from the Endophytic Fungus Phomopsis sp BCC 9789

被引：51

作者：

Bunyapaiboonsri, Taridaporn ^{[1
]}

Yoiprommarat, Seangaroon ^{[1
]}

Srikitikulchai, Prasert ^{[1
]}

Srichomthong, Kitlada ^{[1
]}

Lumyong, Saisaimorn ^{[2
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Klongluang 12120, Pathumthani, Thailand

[2] Chiang Mai Univ, Fac Sci, Dept Biol, Chiang Mai 50200, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 01期

关键词：

METABOLIC PRODUCTS; ASSAY; OBLONGA; DIMERS;

D O I：

10.1021/np900650c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4 alpha-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC(50) = 14 mu M) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC(50) values of 37, 26, 32, and 60 mu M. Cytotoxic activity against the BC cell line was also observed for compound 6, with all IC(50) value of 48 mu M.

引用

页码：55 / 59

页数：5

共 22 条

[1]

BALLIO A, 1966, TETRAHEDRON LETT, V7, P3723

[2] METABOLIC PRODUCTS OF PHOMOPSIS-OBLONGA .1. 3A,5A,6,7,8,9,9A,9B-OCTAHYDRO-7,9B-DIMETHYLNAPHTHO[1,2-C]FURAN-1(3H)-ONE (OBLONGOLIDE) [J].

BEGLEY, MJ ;

GROVE, JF .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (04) :861-863

[3] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[4]

CULVENOR CCJ, 1977, AUST J BIOL SCI, V30, P269, DOI 10.1071/BI9770269

[5] New oblongolides isolated from the endophytic fungus Phomopsis sp from Melilotus dentata from the shores of the Baltic Sea [J].

Dai, JQ ;

Krohn, K ;

Gehle, D ;

Kock, I ;

Flörke, U ;

Aust, HJ ;

Draeger, S ;

Schulz, B ;

Rheinheimer, J .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (18) :4009-4016

[6] METABOLIC PRODUCTS OF PHOMOPSIS-OBLONGA .2. PHOMOPSOLIDE-A AND PHOMOPSOLIDE-B, TIGLIC ESTERS OF 2 6-SUBSTITUTED 5,6-DIHYDRO-5-HYDROXYPYRAN-2-ONES [J].

GROVE, JF .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (04) :865-869

[7] ISOLATION AND CHARACTERIZATION OF PHOMODIOL, A NEW ANTIFUNGAL FROM PHOMOPSIS [J].

HORN, WS ;

SCHWARTZ, RE ;

SIMMONDS, MSJ ;

BLANEY, WM .

TETRAHEDRON LETTERS, 1994, 35 (33) :6037-6040

[8] PHOMOPSICHALASIN, A NOVEL ANTIMICROBIAL AGENT FROM AN ENDOPHYTIC PHOMOPSIS SP [J].

HORN, WS ;

SIMMONDS, MSJ ;

SCHWARTZ, RE ;

BLANEY, WM .

TETRAHEDRON, 1995, 51 (14) :3969-3978

[9] Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species [J].

Isaka, M ;

Jaturapat, A ;

Rukseree, K ;

Danwisetkanjana, K ;

Tanticharoen, M ;

Thebtaranonth, Y .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (08) :1015-1018

[10] Secondary Metabolites of Phomopsis sp XZ-26, an Endophytic Fungus from Camptotheca acuminate [J].

Lin, Ting ;

Lin, Xiang ;

Lu, Chunhua ;

Hu, Zhiyu ;

Huang, Wenyu ;

Huang, Yaojian ;

Shen, Yuemao .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 2009 (18) :2975-2982

← 1 2 3 →