Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome

被引:8
作者
Real de Asua, Diego [1 ,2 ]
Mayer, Miguel A. [3 ,4 ]
del Carmen Ortega, Maria [5 ]
Borrel, Jose M. [6 ]
de Jesus Bermejo, Teresa [7 ]
Gonzalez-Lamuno, Domingo [8 ]
Manso, Coral [9 ]
Moldenhauer, Fernando [1 ,2 ]
Carmona-Iragui, Maria [10 ,11 ]
Huls, Anke [12 ,13 ]
Sherman, Stephanie L. [14 ]
Strydom, Andre [15 ,16 ,17 ]
de la Torre, Rafael [4 ,18 ,19 ]
Dierssen, Mara [4 ,20 ,21 ]
机构
[1] Hosp Univ La Princesa, Dept Internal Med, Adult Syndrome Outpatient Unit, Madrid 28006, Spain
[2] Hosp Univ La Princesa, Inst Invest Sanitaria La Princesa, Madrid 28006, Spain
[3] Hosp del Mar Med Res Inst, Res Programme Biomed Informat, Barcelona 08003, Spain
[4] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain
[5] Hosp Univ 12 Octubre, Dept Psychiat, Res Inst I 12, Madrid 28041, Spain
[6] Down Espana Huesca, Huesca 22005, Spain
[7] Inst Hispalense Pediat, Unidad Neuropediat, Seville 41013, Spain
[8] Univ Cantabria, Univ Hosp Marques de Valdecilla, Dept Pediat, Santander 39008, Spain
[9] Down Espana, Madrid 28043, Spain
[10] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona 08025, Spain
[11] Fundacio Catalana Sindrome Down, Barcelona Down Med Ctr, Barcelona 08029, Spain
[12] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA
[13] Emory Univ, Rollins Sch Publ Hlth, Gangarosa Dept Environm Hlth, Atlanta, GA 30322 USA
[14] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA
[15] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, London SE5 8AF, England
[16] London Down Syndrome LonDownS Consortium, London, England
[17] South London & Maudsley NHS Fdn Trust, London SE5 8AF, England
[18] Hosp del Mar Med Res Inst, Neurosci Res Programme, Barcelona 08003, Spain
[19] Biomed Res Networking Ctr Physiopathol Obes & Nut, Barcelona 08003, Spain
[20] Barcelona Inst Sci & Technol, Ctr Genom Regulat, Barcelona 08003, Spain
[21] Biomed Res Networking Ctr Rare Dis CIBERER, Barcelona 08003, Spain
关键词
down syndrome; COVID-19; SARS-CoV-2; pneumonia; DEMENTIA; RISK;
D O I
10.3390/jcm10163748
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Whether the increased risk for coronavirus disease 2019 (COVID-19) hospitalization and death observed in Down syndrome (DS) are disease specific or also occur in individuals with DS and non-COVID-19 pneumonias is unknown. This retrospective cohort study compared COVID-19 cases in persons with DS hospitalized in Spain reported to the Trisomy 21 Research Society COVID-19 survey (n = 86) with admissions for non-COVID-19 pneumonias from a retrospective clinical database of the Spanish Ministry of Health (n = 2832 patients). In-hospital mortality rates were significantly higher for COVID-19 patients (26.7% vs. 9.4%), especially among individuals over 40 and patients with obesity, dementia, and/or epilepsy. The mean length of stay of deceased patients with COVID-19 was significantly shorter than in those with non-COVID-19 pneumonias. The rate of admission to an ICU in patients with DS and COVID-19 (4.3%) was significantly lower than that reported for the general population with COVID-19. Our findings confirm that acute SARS-CoV-2 infection leads to higher mortality than non-COVID-19 pneumonias in individuals with DS, especially among adults over 40 and those with specific comorbidities. However, differences in access to respiratory support might also account for some of the heightened mortality of individuals with DS with COVID-19.
引用
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页数:11
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