SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 3-(2,2,2-TRICHLORO-1-HYDROXYETHYL)IMIDAZO [1,2-a]BENZIMIDAZOLE DIHYDROCHLORIDES

被引：13

作者：

Anisimova, V. A. ^{[1
]}

Spasov, A. A. ^{[2
,3
,4
]}

Kosolapov, V. A. ^{[2
]}

Tolpygin, I. E. ^{[1
]}

Porotikov, V. I.

Kucheryavenko, A. F.

Sysoeva, V. A. ^{[2
]}

Tibir'kova, E. V. ^{[2
]}

El'tsova, L. V. ^{[2
]}

机构：

[1] So Fed Univ, Res Inst Phys & Organ Chem, Rostov Na Donu, Russia

[2] Volgograd State Med Univ, Pharmacol Res Inst, Volgograd, Russia

[3] Russian Acad Med Sci, Volgograd Sci Ctr, Volgograd, Russia

[4] Volgograd Reg Adm, Volgograd, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 09期

关键词：

synthesis; imidazo[1,2-a]benzimidazoles; trichloroethanols; spasmolytic action; antiaggregant activity; radioprotective properties; antiarrhythmic activity; DERIVATIVES;

D O I：

10.1007/s11094-009-0340-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aseries of 3-(2,2,2-trichloro-1-hydroxyethyl)imidazo[1,2-a]benzimidazole dihydrochlorides have been synthesized and their pharmacological properties have been studied. It is established that the synthesized compounds exhibit weak antioxidant activity. In addition, they possess platelet and erythrocyte antiaggregant properties, show pronounced spasmolytic action, and have low toxicity. Some of them also exhibit antiradiomimetic, hypotensive, and antiarrhythmic properties.

引用

页码：491 / 494

页数：4

共 50 条

[31] Exploration of the CuAAC Reaction for the Synthesis of Novel 3-(Triazol-1-yl)methyl-imidazo[1,2-a]pyridines [J].

Khedar, Poonam ;

Pericherla, Kasiviswanadharaju ;

Kumar, Anil .

SYNLETT, 2012, (18) :2609-2614

[32] Design, synthesis and antimycobacterial activity of novel imidazo[1,2-a]pyridine-3-carboxamide derivatives [J].

Lv, Kai ;

Li, Linhu ;

Wang, Bo ;

Liu, Mingliang ;

Wang, Bin ;

Shen, Weiyi ;

Guo, Huiyuan ;

Lu, Yu .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 137 :117-125

[33] Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indoles [J].

Tiwari, RK ;

Singh, D ;

Singh, J ;

Yadav, V ;

Pathak, AK ;

Dabur, R ;

Chhillar, AK ;

Singh, R ;

Sharma, GL ;

Chandra, R ;

Verma, AK .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (02) :413-416

[34] Synthesis and Antibacterial Activity of 1,2,3,4-Tetrahydro- and Pyrido[1,2-a]Benzimidazoles [J].

Begunov, R. S. ;

Zaitseva, Yu. V. ;

Sokolov, A. A. ;

Egorov, D. O. ;

Filimonov, S. I. .

PHARMACEUTICAL CHEMISTRY JOURNAL, 2022, 56 (01) :22-28

[35] Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles [J].

V. A. Anisimova ;

I. E. Tolpygin ;

A. A. Spasov ;

D. S. Yakovlev ;

N. A. Kolobrodova ;

N. A. Gurova ;

O. A. Salaznikova ;

L. V. Naumenko ;

V. A. Kosolapov ;

L. V. El’tsova ;

T. M. Mitina ;

M. P. Voronkova ;

K. V. Lenskaya .

Pharmaceutical Chemistry Journal, 2012, 46 :325-330

[36] A NEW APPROACH TO IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR APPLICATION TO THE SYNTHSES OF NOVEL 2H-PYRANO[2′,3′:4,5] IMIDAZO[1,2-a]PYRIDIN-2-ONE DERIVATIVES [J].

Abe, Takashi ;

Okumura, Yukihisa ;

Suga, Hiroyuki ;

Kakehi, Akikazu .

HETEROCYCLES, 2010, 80 (01) :439-454

[37] Azacycloalkanes. XXXIV. Synthesis and antiarrhythmic activity of 2-(2′-R-2′-hydroxyethyl)-1,2,3,4-tetra-hydro-pyrrolo-[1,2-a] pyrazines [J].

A. M. Likhosherstov ;

O. V. Filippova ;

V. P. Peresada ;

S. A. Kryzhanovskii ;

M. B. Vititnova ;

N. V. Kaverina ;

K. M. Reznikov .

Pharmaceutical Chemistry Journal, 2003, 37 (1) :6-9

[38] New Approach to the Synthesis of 2-Sulfonylaminosubstituted Imidazo[1,2-a]pyridines via the Cascade Reaction of N-(1-aryl-2,2,2-trichloroethyl) sulfonamides with 2-Aminopyridines [J].

Serykh, Valery Yu ;

Ushakov, Igor A. ;

Borodina, Tatyana N. ;

Smirnov, Vladimir, I ;

Rozentsveig, Igor B. .

CHEMISTRYSELECT, 2019, 4 (46) :13485-13489

[39] Synthesis and antiaggregant activity of 3-(2-Aryl-2-oxoethyl)-3-methoxy-2-oxo-2,3-dihydroimidazo[1,2-a]pyridine hydrochlorides [J].

Kataev S.S. ;

Syropyatov B.Ya. ;

Gavrilova N.E. ;

Zalesov V.V. .

Pharmaceutical Chemistry Journal, 2004, 38 (4) :181-182

[40] Design, Synthesis and Insecticidal Activity of Novel Phenylpyrazoles Containing a 2,2,2-Trichloro-1-alkoxyethyl Moiety [J].

Zhao, Qiqi ;

Li, Yongqiang ;

Xiong, Lixia ;

Wang, Qingmin .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (08) :4992-4998

← 1 2 3 4 5 →