Comparing prognostic utility between the 8th edition of TNM staging system and the lymph node ratio for oral squamous cell carcinoma

被引：15

作者：

Beltramini, Giada A. ^{[1
]}

Belloni, Laura M. ^{[1
]}

Fusco, Nicola ^{[2
,3
]}

Sacconi, Andrea ^{[4
]}

Muti, Paola ^{[2
]}

Baj, Alessandro ^{[1
,2
]}

Bolzoni, Alessandro R. ^{[1
,2
]}

Gianni, Aldo B. ^{[1
,2
]}

机构：

[1] Osped Maggiore Policlin Milano, Maxillofacial Surg & Odontostomatol Unit, IRCCS Fdn Ca Granda, 35 Francesco Sforza, I-20122 Milan, Italy

[2] Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy

[3] Osped Maggiore Policlin Milano, Div Pathol, IRCCS Fdn Ca Granda, Milan, Italy

[4] IRCCS Regina Elena Natl Canc Inst, UOSD Clin Trial Ctr, Biostat & Bioinformat, Rome, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2021年 / 43卷 / 10期

关键词：

lymph node ratio; neck dissection; neoplasm recurrence; oral cancer; survival; NECK DISSECTION; CANCER; HEAD; CHEMOTHERAPY; DENSITY; NUMBER; METASTASES; PREDICTOR; SURVIVAL; YIELD;

D O I：

10.1002/hed.26769

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Lymph node metastasis in oral squamous cell carcinoma (OSCC) is associated with poor prognosis. The 8th edition of TNM has implemented new nodal staging criteria. We assess the prognostic utility of the lymph node ratio (LNR) and compare it to that of pN in the TNM 8th edition. Methods One hundred and forty-two patients with OSCC were retrospectively studied. Nodal staging was performed using the TMN 8th edition and the prognostic value of the LNR in terms of overall survival (OS) and disease-free survival (DFS) was evaluated. Results Fifty-seven patients were eligible for inclusion. The LNR was independently prognostic of OS (p = 0.02). Instead N classification was not significantly predictive of OS (p = 0.10). High LNRs resulted in decreases in OS of approximately 40% within 6 months after surgery. Conclusions The LNR identifies patients with poor outcomes better than N classification. The lack of reliable LNR cutoffs compromises its utility in clinical practice.

引用

页码：2876 / 2882

页数：7

共 36 条

[21] Primary chemotherapy in resectable oral cavity squamous cell cancer:: A randomized controlled trial [J].

Licitra, L ;

Grandi, C ;

Guzzo, M ;

Mariani, L ;

Lo Vullo, S ;

Valvo, F ;

Quattrone, P ;

Valagussa, P ;

Bonadonna, G ;

Molinari, R ;

Cantù, G .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (02) :327-333

[22] Important prognostic significance of lymph node density in patients with node positive oral tongue cancer [J].

Lieng, Hester ;

Gebski, Val J. ;

Morgan, Gary J. ;

Veness, Michael J. .

ANZ JOURNAL OF SURGERY, 2016, 86 (09) :681-686

[23] Postoperative staging of the neck dissection using extracapsular spread and lymph node ratio as prognostic factors in HPV-negative head and neck squamous cell carcinoma patients [J].

Majercakova, Katarina ;

Valero, Cristina ;

Lopez, Montserrat ;

Garcia, Jacinto ;

Farre, Nuria ;

Quer, Miquel ;

Leon, Xavier .

ORAL ONCOLOGY, 2018, 77 :37-42

[24] Induction chemotherapy prior to surgery with or without postoperative radiotherapy for oral cavity cancer patients: Systematic review and meta-analysis [J].

Marta, Gustavo N. ;

Riera, Rachel ;

Bossi, Paolo ;

Zhong, Lai-ping ;

Licitra, Lisa ;

Macedo, Cristiane R. ;

de Castro Junior, Gilberto ;

Carvalho, Andre L. ;

William, William N., Jr. ;

Kowalski, Luis Paulo .

EUROPEAN JOURNAL OF CANCER, 2015, 51 (17) :2596-2603

[25] The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx:: N0 versus N+ [J].

Mayland, MK ;

Sessions, DG ;

Lenox, J .

LARYNGOSCOPE, 2005, 115 (04) :629-639

[26] Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research [J].

Patel, S. G. ;

Amit, M. ;

Yen, T. C. ;

Liao, C. T. ;

Chaturvedi, P. ;

Agarwal, J. P. ;

Kowalski, L. P. ;

Ebrahimi, A. ;

Clark, J. R. ;

Cernea, C. R. ;

Brandao, S. J. ;

Kreppel, M. ;

Zoeller, J. ;

Fliss, D. ;

Fridman, E. ;

Bachar, G. ;

Shpitzer, T. ;

Bolzoni, V. A. ;

Patel, P. R. ;

Jonnalagadda, S. ;

Robbins, K. T. ;

Shah, J. P. ;

Gil, Z. .

BRITISH JOURNAL OF CANCER, 2013, 109 (08) :2087-2095

[27] Prognostic determinants of locally advanced buccal mucosa cancer: Do we need to relook the current staging criteria? [J].

Pillai, Vijay ;

Yadav, Vishal ;

Kekatpure, Vikram ;

Trivedi, Nirav ;

Chandrashekar, Naveen Hedne ;

Shetty, Vivek ;

Rangappa, Vidyabhushan ;

Subramaniam, Narayana ;

Bhat, Venkatraman ;

Raghavan, Nisheena ;

Kolur, Trupti ;

George, Nivya ;

Thomas, Tinku ;

Kuriakose, Moni Abraham .

ORAL ONCOLOGY, 2019, 95 :43-51

[28] Number of positive nodes is superior to the lymph node ratio and American Joint Committee on Cancer N staging for the prognosis of surgically treated head and neck squamous cell carcinomas [J].

Roberts, Thomas J. ;

Colevas, A. Dimitrios ;

Hara, Wendy ;

Holsinger, F. Christopher ;

Oakley-Girvan, Ingrid ;

Divi, Vasu .

CANCER, 2016, 122 (09) :1388-1397

[29] Metastasis of squamous cell carcinoma of the oral tongue [J].

Sano, Daisuke ;

Myers, Jeffrey N. .

CANCER AND METASTASIS REVIEWS, 2007, 26 (3-4) :645-662

[30] Lymph node ratio as a prognostic factor for survival in patients with head and neck squamous cell carcinoma [J].

Sano, Daisuke ;

Yabuki, Kenichiro ;

Takahashi, Hideaki ;

Arai, Yasuhiro ;

Chiba, Yoshihiro ;

Tanabe, Teruhiko ;

Nishimura, Goshi ;

Oridate, Nobuhiko .

AURIS NASUS LARYNX, 2018, 45 (04) :846-853

← 1 2 3 4 →