Effector T cell plasticity: flexibility in the face of changing circumstances

被引：367

作者：

Murphy, Kenneth M. ^{[1
]}

Stockinger, Brigitta ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Natl Inst Med Res, MRC, Div Mol Immunol, London NW7 1AA, England

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 08期

关键词：

ARYL-HYDROCARBON RECEPTOR; FOLLICULAR-HELPER-CELLS; CXC CHEMOKINE RECEPTOR-5; TH17; CELLS; RETINOIC-ACID; ROR-GAMMA; IFN-GAMMA; TGF-BETA; IN-VIVO; LINEAGE DIFFERENTIATION;

D O I：

10.1038/ni.1899

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.

引用

页码：674 / 680

页数：7

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