Biocompatible multi-walled carbon nanotube-CdTe quantum dot-polymer hybrids for medical applications

被引：18

作者：

Baslak, Canan ^{[1
,2
]}

Kars, Meltem Demirel ^{[1
,3
]}

Karaman, Mustafa ^{[1
,4
]}

Kus, Mahmut ^{[1
,4
]}

Cengeloglu, Yunus ^{[1
,2
]}

Ersoz, Mustafa ^{[1
,2
]}

机构：

[1] Selcuk Univ, Adv Technol Res & Applicat Ctr, TR-42075 Konya, Turkey

[2] Selcuk Univ, Fac Sci, Dept Chem, TR-42075 Konya, Turkey

[3] Selcuk Univ, Sarayonu Vocat High Sch, TR-42075 Konya, Turkey

[4] Selcuk Univ, Fac Engn, Dept Chem Engn, TR-42075 Konya, Turkey

来源：

JOURNAL OF LUMINESCENCE | 2015年 / 160卷

关键词：

Quantum dots; Carbon nanotubes; CNT-QD hybrids; Biocompatibility; Live cell imaging; CHEMICAL-VAPOR-DEPOSITION; BIOMEDICAL APPLICATIONS; ANTIMICROBIAL ACTIVITY; SURFACE MODIFICATION; HIGH-QUALITY; THIN-FILMS; IN-VITRO; NANOCRYSTALS; CELLS; POLY(AMIDOAMINE);

D O I：

10.1016/j.jlumin.2014.11.030

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Herein we report the synthesis of polymer coated quantum dots (QDs)-carbon nanotube composite material with high biocompatibility and low cellular toxicity. The synthesized multi-walled carbon nanotube (MWCNT)-QD-(-poly(glycidyl methacrylate)) (pGMA) hybrids were characterized using X-ray photoelectron spectroscopy, laser scanning confocal microscopy, transmission electron microscopy and scanning electron microscopy. The results showed that quantum dots were well-distributed on nanotube surfaces in high density. The toxicological assessments of QDs and MWCNT-QD-polymer hybrids in human mammary carcinoma cells and their fluorescence imaging in living cell system were carried out. MWCNT-QD-polymer hybrids possess intense red fluorescence signal under confocal microscopy and good fluorescence stability over 6-h exposure in living cell system. The toxicity comparison of QDs and MWCNT-QD-polymer hybrids has shown that the existence of PGMA thin coating on MWCNT-QD hybrid surface decreased the cellular toxicity and increased biocompatibility. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：9 / 15

页数：7

共 47 条

[1] InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared [J].