Influence of thyroid gland status on the thyroglobulin cutoff level in washout fluid from cervical lymph nodes of patients with recurrent/metastatic papillary thyroid cancer

被引：18
作者：
Lee, Jun Ho [1 ]
Lee, Hyun Chul [2 ]
Yi, Ha Woo [2 ]
Kim, Bong Kyun [2 ]
Bae, Soo Youn [2 ]
Lee, Se Kyung [2 ]
Choe, Jun-Ho [2 ]
Kim, Jung-Han [2 ]
Kim, Jee Soo [2 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Dept Surg, Chang Won, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg,Div Breast & Endocrine Surg, 81 Irwon Ro, Seoul 135710, South Korea
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷
关键词：
fine-needle aspiration; washout thyroglobulin; cutoff value; serum thyroglobulin; thyroidectomy; FINE-NEEDLE-ASPIRATION; DIAGNOSTIC-VALUE; BIOPSY; CARCINOMA; METASTASES; ULTRASOUND; MASSES;
D O I：
10.1002/hed.24305
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. The influence of serum thyroglobulin (Tg) and thyroidectomy status on Tg in fine-needle aspiration cytology (FNAC) washout fluid is unclear. Methods. A total of 282 lymph nodes were prospectively subjected to FNAC, fine-needle aspiration (FNA)-Tg measurement, and frozen and permanent biopsies. We evaluated the diagnostic performance of several predetermined FNA-Tg cutoff values for recurrence/metastasis in lymph nodes according to thyroidectomy status. Results. The diagnostic performance of FNA-Tg varied according to thyroidectomy status. The optimized cutoff value of FNA-Tg was 2.2 ng/mL. However, among FNAC-negative lymph nodes, the FNA-Tg cutoff value of 0.9 ng/mL showed better diagnostic performance in patients with a thyroid gland. An FNA-Tg/serum-Tg cutoff ratio of 1 showed the best diagnostic performance in patients without a thyroid gland. Conclusion. Applying the optimal cutoff values of FNA-Tg according to thyroid gland status and serum Tg level facilitates the diagnostic evaluation of neck lymph node recurrences/metastases in patients with papillary thyroid carcinoma (PTC). (C) 2015 Wiley Periodicals, Inc.
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页码：E1705 / E1712
页数：8
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