Nuclease activity and anti-proliferative effect on human cancerous cells of a newly synthesized and characterized mononuclear copper(II) complex [CuII(L)(fu)2] [L=2-(2-pyridyl)benzimidazole, fu = furoate]

被引：35

作者：

Mal, Sunit Kumar ^{[1
]}

Mitra, Merry ^{[1
]}

Kaur, Gurpreet ^{[2
]}

Manikandamathavan, V. M. ^{[3
]}

Kiran, Manikantan Syamala ^{[4
]}

Choudhury, Angshuman Roy ^{[2
]}

Nair, Balachandran Unni ^{[3
]}

Ghosh, Rajarshi ^{[1
]}

机构：

[1] Univ Burdwan, Dept Chem, Burdwan 713104, W Bengal, India

[2] Indian Inst Sci Educ & Res, Dept Chem Sci, Mohali 140306, India

[3] Cent Leather Res Inst, CSIR, Chem Lab, Madras 600020, Tamil Nadu, India

[4] Cent Leather Res Inst, CSIR, Biomat Lab, Madras 600020, Tamil Nadu, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 106期

关键词：

LUMINESCENT PROPERTIES; CRYSTAL-STRUCTURES; DNA; ZINC(II); LIGANDS; BINDING; DERIVATIVES; AGENT; LIGHT;

D O I：

10.1039/c4ra09448d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mononuclear copper(II) complex [Cu-II(L)(fu)(2)] (1) [L = 2-(2- pyridyl)benzimidazole, fu = furoate] has been synthesized and characterized by X-ray crystallography. Structural analysis reveals that 1 adopts a distorted square pyramidal geometry with CuN2O3 chromophore. Spectrophotometric and hydrodynamic investigations suggest that the complex binds with DNA in an intercalative mode with a binding constant of (3.19 +/- 0.32) x 10(4) M-1. 1 induces oxidative cleavage of the supercoiled DNA to its nicked circular as well as linear forms. 1 is also proved to be an anti-cancer agent on human keratinocyte cells.

引用

页码：61337 / 61342

页数：6

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