HDGF: a novel jack-of-all-trades in cancer

被引：76
作者：
Bao, Cihang [1 ]
Wang, Jianbo [1 ]
Ma, Wei [2 ]
Wang, Xintong [1 ]
Cheng, Yufeng [1 ]
机构：
[1] Shandong Univ, Dept Radiat Oncol, Qilu Hosp, Jinan 250012, Peoples R China
[2] Ningxia Med Univ, Gen Hosp, Dept Radiat Oncol, Canc Hosp, Yinchuan, Peoples R China
来源：
FUTURE ONCOLOGY | 2014年 / 10卷 / 16期
关键词：
angiogenesis; apoptosis; epithelial-to-mesencyhmal transition; hepatoma-derived growth factor; metastasis; molecular mechanisms; prognosis; PWWP; HATH domain; serum levels; tumorigenesis; CELL LUNG-CANCER; GROWTH-FACTOR HDGF; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN HEPATOCELLULAR-CARCINOMA; MEDIATED APOPTOTIC PATHWAY; DOWN-REGULATION; PROGNOSTIC-FACTOR; GENE-EXPRESSION; HUMAN HEPATOMA; TARGETING HDGF;
D O I：
10.2217/fon.14.194
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
HDGF is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell transformation, apoptosis, angiogenesis and metastasis. Such a divergent influence of HDGF on cancer cell activities derives from its multiple inter- and sub-cellular localizations where it interacts with a range of different binding partners. Interestingly, high levels of HDGF could be detected in patients' serum of some cancers. This review is focused on the role of HDGF in tumorigenesis and metastasis, and provides insight for application in clinical cancer therapy as well as its clinical implications as a prognostic marker in cancer progression.
引用
收藏
页码：2675 / 2685
页数：11
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