Effect of pH on chitosan hydrogel polymer network structure

被引：86

作者：

Xu, Hongcheng ^{[1
]}

Matysiak, Silvina ^{[1
,2
]}

机构：

[1] Univ Maryland, Inst Phys Sci & Technol, Biophys Program, College Pk, MD 20742 USA

[2] Univ Maryland, Fischell Dept Engn, College Pk, MD 20742 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 53期

关键词：

ALGORITHMS; POLYSACCHARIDE; FORM; GELS;

D O I：

10.1039/c7cc01826f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chitosan is a molecule that can form water-filled 3D polymer networks with a wide range of applications. A new coarse-grained model for chitosan hydrogel was developed to explore its pH-dependent self-assembly behavior and mechanical properties. Our results indicate that the underlying polymer physical crosslinking pattern induced by solution pH has a significant effect on hydrogel elastic moduli. With this model, we obtain pH-dependent structural and mechanical property changes in agreement with experimental observations, and provide a molecular mechanism behind the changes in polymer crosslinking patterns.

引用

页码：7373 / 7376

页数：4

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