The Reproductive Injury and Oxidative Testicular Toxicity Induced by Chlorpyrifos Can Be Restored by Zinc in Male Rats

被引：15
作者：
Khalaf, Abdel Azem [1 ]
Ogaly, Hanan A. [2 ]
Ibrahim, Marwa A. [3 ]
Abdallah, Amr A. [4 ]
Zaki, Amr R. [4 ]
Tohamy, Adel F. [1 ]
机构：
[1] Cairo Univ, Dept Forens Med & Toxicol, Fac Vet Med, Giza, Egypt
[2] King Khalid Univ, Chem Dept, Fac Sci, Abha, Saudi Arabia
[3] Cairo Univ, Dept Biochem & Mol Biol, Fac Vet Med, Giza, Egypt
[4] Cent Lab Pesticides, Giza, Egypt
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2022年 / 200卷 / 02期
关键词：
Chlorpyrifos; Zinc; Reproductive injury; Genotoxicity; Oxidative testicular toxicity; TITANIUM-DIOXIDE NANOPARTICLES; DRINKING-WATER; TRACE-ELEMENT; EXPOSURE; HEALTH; SUPPLEMENTATION; TESTOSTERONE; CYPERMETHRIN; PESTICIDE; MALATHION;
D O I：
10.1007/s12011-021-02704-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The current study aimed to evaluate the harmful effect of chlorpyrifos (CPF) on the reproductive functions and fertility in male rats and to assess the protective role of zinc (Zn) in improving the adverse effects of CPF on male fertility. Sixty mature male rats were divided into four groups: Group 1: The control group was orally administered with the corresponding dose of corn oil. Group 2 animals received chlorpyrifos (1 mg/kg, oral). Group 3 rats received oral zinc (25 mg/kg) daily. Group 4 animals received oral zinc treatment (25 mg/kg). CPF caused a significant decrease in the body and reproductive organs' weights, sperm count, sperm motility percent, serum testosterone, FSH, and LH. The CPF-treated group showed a significant increase in dead sperm percent and sperm abnormalities. CPF induced a significant internucleosomal DNA fragmentation and marked histological alterations in the testes of treated male rats. Conversely, co-treatment with Zn improved the reproductive organs weights, sperm characteristics, internucleosomal DNA fragmentation, and histological alterations of the testes. In conclusion, CPF triggered significant detrimental effects on male reproductive organs and functions and the co-treatment with zinc partly alleviate the injurious effects of CPF on male fertility.
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收藏
页码：551 / 559
页数：9
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