Titin: central player of hypertrophic signaling and sarcomeric protein quality control

被引：35

作者：

Koetter, Sebastian ^{[1
]}

Andresen, Christian ^{[1
]}

Krueger, Martina ^{[1
]}

机构：

[1] Univ Dusseldorf, Dept Cardiovasc Physiol, D-40225 Dusseldorf, Germany

来源：

BIOLOGICAL CHEMISTRY | 2014年 / 395卷 / 11期

关键词：

chaperones; connectin; heat shock proteins; UBIQUITIN-PROTEASOME SYSTEM; ALPHA-B-CRYSTALLIN; HEAT-SHOCK PROTEINS; HUMAN DILATED CARDIOMYOPATHY; MOLECULE FORCE SPECTROSCOPY; RING FINGER PROTEINS; MUSCLE LIM PROTEIN; MATRIX METALLOPROTEINASE-2; PASSIVE STIFFNESS; SKELETAL-MUSCLE;

D O I：

10.1515/hsz-2014-0178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The giant sarcomeric protein titin has multiple important functions in striated muscle cells. Due to its gigantic size, its central position in the sarcomere and its elastic I-band domains, titin is a scaffold protein that is important for sarcomere assembly, and serves as a molecular spring that defines myofilament distensibility. This review focuses on the emerging role of titin in mechanosensing and hypertrophic signaling, and further highlights recent evidence that links titin to sarcomeric protein turnover.

引用

页码：1341 / 1352

页数：12

共 125 条

[91] The ubiquitin-proteasome system in myocardial ischaemia and preconditioning [J].

Powell, Saul R. ;

Divald, Andras .

CARDIOVASCULAR RESEARCH, 2010, 85 (02) :303-311

[92] Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles [J].

Prado, LG ;

Makarenko, I ;

Andresen, C ;

Krüger, M ;

Opitz, CA ;

Linke, WA .

JOURNAL OF GENERAL PHYSIOLOGY, 2005, 126 (05) :461-480

[93] Ubiquitin Proteasome Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies [J].

Predmore, Jaime M. ;

Wang, Ping ;

Davis, Frank ;

Bartolone, Sarah ;

Westfall, Margaret V. ;

Dyke, David B. ;

Pagani, Francis ;

Powell, Saul R. ;

Day, Sharlene M. .

CIRCULATION, 2010, 121 (08) :997-U33

[94] A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics [J].

Raskin, Anna ;

Lange, Stephan ;

Banares, Katherine ;

Lyon, Robert C. ;

Zieseniss, Anke ;

Lee, Leonard K. ;

Yamazaki, Katrina G. ;

Granzier, Henk L. ;

Gregorio, Carol C. ;

McCulloch, Andrew D. ;

Omens, Jeffrey H. ;

Sheikh, Farah .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (35) :29273-29284

[95] Calpain 1-titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril [J].

Raynaud, F ;

Fernandez, E ;

Coulis, G ;

Aubry, L ;

Vignon, X ;

Bleimling, N ;

Gautel, M ;

Benyamin, Y ;

Ouali, A .

FEBS JOURNAL, 2005, 272 (10) :2578-2590

[96] Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart [J].

Razeghi, P ;

Baskin, KK ;

Sharma, S ;

Young, ME ;

Stepkowski, S ;

Essop, MF ;

Taegtmeyer, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 342 (02) :361-364

[97] The mechanical stability of immunoglobulin and fibronectin III domains in the muscle protein titin measured by atomic force microscopy [J].

Rief, M ;

Gautel, M ;

Schemmel, A ;

Gaub, HE .

BIOPHYSICAL JOURNAL, 1998, 75 (06) :3008-3014

[98] MYOFIBRILLOGENESIS IN LIVING CELLS MICROINJECTED WITH FLUORESCENTLY LABELED ALPHA-ACTININ [J].

SANGER, JM ;

MITTAL, B ;

POCHAPIN, MB ;

SANGER, JW .

JOURNAL OF CELL BIOLOGY, 1986, 102 (06) :2053-2066

[99] Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury - A new intracellular target for matrix metalloproteinase-2 [J].

Sawicki, G ;

Leon, H ;

Sawicka, J ;

Sariahmetoglu, M ;

Schulze, CJ ;

Scott, PG ;

Szczesna-Cordary, D ;

Schulz, R .

CIRCULATION, 2005, 112 (04) :544-552

[100] The ubiquitin-proteasome system in cardiomyopathies [J].

Schlossarek, Saskia ;

Carrier, Lucie .

CURRENT OPINION IN CARDIOLOGY, 2011, 26 (03) :190-195

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