Titin: central player of hypertrophic signaling and sarcomeric protein quality control

被引：35

作者：

Koetter, Sebastian ^{[1
]}

Andresen, Christian ^{[1
]}

Krueger, Martina ^{[1
]}

机构：

[1] Univ Dusseldorf, Dept Cardiovasc Physiol, D-40225 Dusseldorf, Germany

来源：

BIOLOGICAL CHEMISTRY | 2014年 / 395卷 / 11期

关键词：

chaperones; connectin; heat shock proteins; UBIQUITIN-PROTEASOME SYSTEM; ALPHA-B-CRYSTALLIN; HEAT-SHOCK PROTEINS; HUMAN DILATED CARDIOMYOPATHY; MOLECULE FORCE SPECTROSCOPY; RING FINGER PROTEINS; MUSCLE LIM PROTEIN; MATRIX METALLOPROTEINASE-2; PASSIVE STIFFNESS; SKELETAL-MUSCLE;

D O I：

10.1515/hsz-2014-0178

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The giant sarcomeric protein titin has multiple important functions in striated muscle cells. Due to its gigantic size, its central position in the sarcomere and its elastic I-band domains, titin is a scaffold protein that is important for sarcomere assembly, and serves as a molecular spring that defines myofilament distensibility. This review focuses on the emerging role of titin in mechanosensing and hypertrophic signaling, and further highlights recent evidence that links titin to sarcomeric protein turnover.

引用

页码：1341 / 1352

页数：12

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