9,11-Secosteroids and polyhydroxylated steroids from two South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis

被引：35

作者：

Chen, Wen-Ting ^{[1
]}

Liu, Hai-Li ^{[1
]}

Yao, Li-Gong ^{[1
]}

Guo, Yue-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

STEROIDS | 2014年 / 92卷

关键词：

Soft coral; Sarcophyton trocheliophorum; Sinularia flexibilis; 9,11-Secosteroid; Polyhydroxylated steroid; POLYOXYGENATED STEROIDS; DITERPENOIDS; METABOLITES; INHIBITOR; CHEMISTRY;

D O I：

10.1016/j.steroids.2014.08.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new 9,11-secosteroid, 25(26)-dehydrosarcomilasterol (1), two new polyhydroxylated steroids, 7 alpha-hydroxy-crassarosterol A (2) and 11-acetoxy-7 alpha-hydroxy-crassarosterol A (3), together with three known related ones (4-6), were isolated from the South China Sea soft corals Sarcophyton trocheliophorum and Sinularia flexibilis, respectively. The structures of the new steroids were elucidated on the basis of extensive spectroscopic analyses, comparison with the literature data and chemical correlation. Compound 2 exhibited a moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 33.05 mu M. Compounds 1-3 showed weak in vitro cytotoxicities against the tumor cell lines 1(562 and HL-60. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：56 / 61

页数：6

共 33 条

[1] Sinugrandisterols A-D, trihydroxysteroids from the soft coral Sinularia gyandilobata [J].