Endonasal phototherapy with Rhinolight® for the treatment of allergic rhinitis

被引:2
作者
Brehmer, Detlef [1 ,2 ]
机构
[1] Univ Witten Herdecke, Fac Med, D-37073 Gottingen, Germany
[2] Private ENT Clin Goettingen, Gottingen, Germany
关键词
allergic rhinitis; phototherapy; Rhinolight (R); ultraviolet therapy; CONTACT HYPERSENSITIVITY; SUBLINGUAL IMMUNOTHERAPY; DOUBLE-BLIND; T-CELL; ULTRAVIOLET; INDUCTION; IRRADIATION; INHIBITION; MECHANISMS; INJECTIONS;
D O I
10.1586/ERD.09.56
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Allergic rhinitis, although not life threatening, significantly affects the quality of the patient's daily life. The three major steps in the treatment of the condition are avoidance of allergens, treatment of symptoms (in particular, antihistaminics and topical nasal corticosteroids) and specific immunotherapy. Avoidance of the allergen is usually not possible and symptom relief is often limited, despite the availability of a number of pharmacological options. Specific immunotherapy demands a high level of cooperation on the part of the patient for at least 3 years. Endonasal phototherapy with the Rhinolight (R) device (Rhinolight Ltd, Szeged, Hungary) for the treatment of immunoglobulin E-mediated allergic rhinitis is a new option that utilizes the immunosuppressive effects of UV radiation. The method directs a combination of UV-B (5%), UV-A (25%) and visible light (70%) into the nasal cavity, and its effectiveness has been demonstrated in one double-blind, placebo-controlled study. The results of additional studies have been presented at various medical conferences and in abstracts. Reports in the literature confirm that phototherapy is a well-established and successful treatment of atopic dermatitis and other skin diseases.
引用
收藏
页码:21 / 26
页数:6
相关论文
共 49 条
[1]   IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy [J].
Akdis, CA ;
Blaser, K .
FASEB JOURNAL, 1999, 13 (06) :603-609
[2]   Mechanisms and treatment of allergic disease in the big picture of regulatory T cells [J].
Akdis, Cezmi A. ;
Akdis, Muebeccel .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (04) :735-746
[3]   Mechanisms of allergen-specific immunotherapy [J].
Akdis, Muebeccel ;
Akdis, Cezmi A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (04) :780-789
[4]  
[Anonymous], 2007, COCHRANE DB SYST REV
[5]   IDENTIFICATION OF THE MOLECULAR TARGET FOR THE SUPPRESSION OF CONTACT HYPERSENSITIVITY BY ULTRAVIOLET-RADIATION [J].
APPLEGATE, LA ;
LEY, RD ;
ALCALAY, J ;
KRIPKE, ML .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1117-1131
[6]  
ASSENOVA K, 2009, GMS CURR POSTERS OTO, DOI DOI 10.3205/09HNOD323
[7]  
*AUTH HOUS LORDS, 2007, ALL, V1
[8]   Role of immunomodulation in diseases responsive to phototherapy [J].
Beissert, S ;
Schwarz, T .
METHODS, 2002, 28 (01) :138-144
[9]  
BELLA Z, 2007, WORLD ALLERGY ORGAN, DOI DOI 10.1097/01.WOX.0000301345.36484.E0
[10]   Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001 [J].
Bernstein, DI ;
Wanner, M ;
Borish, L ;
Liss, GM .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (06) :1129-1136