High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicine

被引：106

作者：

Gatalica, Zoran ^{[1
]}

Vranic, Semir ^{[2
]}

Xiu, Joanne ^{[1
]}

Swensen, Jeffrey ^{[1
]}

Reddy, Sandeep ^{[1
]}

机构：

[1] Caris Life Sci, 4610 South,44th Pl, Phoenix, AZ 85040 USA

[2] Univ Clin Ctr Sarajevo, Dept Pathol, Sarajevo, Bosnia & Herceg

来源：

FAMILIAL CANCER | 2016年 / 15卷 / 03期

关键词：

Colorectal cancer; Microsatellite instability; Lynch syndrome; Biomarkers; Conventional chemotherapy; Targeted therapy; GENE COPY NUMBERS; MISMATCH-REPAIR; THYMIDYLATE SYNTHASE; LYNCH-SYNDROME; ADJUVANT CHEMOTHERAPY; PD-1; BLOCKADE; CANCER; METHYLATION; ASSOCIATION; MUTATIONS;

D O I：

10.1007/s10689-016-9884-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Approximately 15 % of colorectal carcinomas (CRC) display high level microsatellite instability (MSI-H) due to either a germline mutation in one of the genes responsible for DNA mismatch repair (Lynch syndrome, 3 %) or somatic inactivation of the same pathway, most commonly through hypermethylation of the MLH1 gene (sporadic MSI-H, 12 %). Although heterogeneous, MSI-H colorectal carcinomas as a group show some distinct biologic characteristics when compared to CRC with stable or low level microsatellite instability. In the present review we will highlight therapeutically relevant characteristics of MSI-H tumors which could lead to specific responses to some conventional chemotherapy or novel targeted therapy agents.

引用

页码：405 / 412

页数：8

共 59 条

[11] BIOMARKERS OF TARGETED THERAPIES IN MALIGNANT PHYLLODES TUMORS OF THE BREAST [J].

Gatalica, Z. ;

Basu, G. ;

Ghazalpour, A. ;

Bender, R. ;

Vranic, S. ;

Millis, S. ;

McGill, J. ;

Voss, A. .

ANNALS OF ONCOLOGY, 2014, 25

[12] Pathology of the hereditary colorectal carcinoma [J].

Gatalica, Zoran ;

Torlakovic, Emina .

FAMILIAL CANCER, 2008, 7 (01) :15-26

[13] Programmed Cell Death 1 (PD-1) and Its Ligand (PD-L1) in Common Cancers and Their Correlation with Molecular Cancer Type [J].

Gatalica, Zoran ;

Snyder, Carrie ;

Maney, Todd ;

Ghazalpour, Anatole ;

Holterman, Daniel A. ;

Xiao, Nianqing ;

Overberg, Peggy ;

Rose, Inga ;

Basu, Gargi D. ;

Vranic, Semir ;

Lynch, Henry T. ;

Von Hoff, Daniel D. ;

Hamid, Omid .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2014, 23 (12) :2965-2970

[14] Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer [J].

Gonzalo, Victoria ;

Jose Lozano, Juan ;

Munoz, Jenifer ;

Balaguer, Francesc ;

Pellise, Maria ;

Rodriguez de Miguel, Cristina ;

Andreu, Montserrat ;

Jover, Rodrigo ;

Llor, Xavier ;

Dolores Giraldez, M. ;

Ocana, Teresa ;

Serradesanferm, Anna ;

Alonso-Espinaco, Virginia ;

Jimeno, Mireya ;

Cuatrecasas, Miriam ;

Sendino, Oriol ;

Castellvi-Bel, Sergi ;

Castells, Antoni .

PLOS ONE, 2010, 5 (01)

[15] The consensus molecular subtypes of colorectal cancer [J].

Guinney, Justin ;

Dienstmann, Rodrigo ;

Wang, Xin ;

de Reynies, Aurelien ;

Schlicker, Andreas ;

Soneson, Charlotte ;

Marisa, Laetitia ;

Roepman, Paul ;

Nyamundanda, Gift ;

Angelino, Paolo ;

Bot, Brian M. ;

Morris, Jeffrey S. ;

Simon, Iris M. ;

Gerster, Sarah ;

Fessler, Evelyn ;

Melo, Felipe De Sousa E. ;

Missiaglia, Edoardo ;

Ramay, Hena ;

Barras, David ;

Homicsko, Krisztian ;

Maru, Dipen ;

Manyam, Ganiraju C. ;

Broom, Bradley ;

Boige, Valerie ;

Perez-Villamil, Beatriz ;

Laderas, Ted ;

Salazar, Ramon ;

Gray, Joe W. ;

Hanahan, Douglas ;

Tabernero, Josep ;

Bernards, Rene ;

Friend, Stephen H. ;

Laurent-Puig, Pierre ;

Medema, Jan Paul ;

Sadanandam, Anguraj ;

Wessels, Lodewyk ;

Delorenzi, Mauro ;

Kopetz, Scott ;

Vermeulen, Louis ;

Tejpar, Sabine .

NATURE MEDICINE, 2015, 21 (11) :1350-1356

[16] Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients [J].

Herbst, Roy S. ;

Soria, Jean-Charles ;

Kowanetz, Marcin ;

Fine, Gregg D. ;

Hamid, Omid ;

Gordon, Michael S. ;

Sosman, Jeffery A. ;

McDermott, David F. ;

Powderly, John D. ;

Gettinger, Scott N. ;

Kohrt, Holbrook E. K. ;

Horn, Leora ;

Lawrence, Donald P. ;

Rost, Sandra ;

Leabman, Maya ;

Xiao, Yuanyuan ;

Mokatrin, Ahmad ;

Koeppen, Hartmut ;

Hegde, Priti S. ;

Mellman, Ira ;

Chen, Daniel S. ;

Hodi, F. Stephen .

NATURE, 2014, 515 (7528) :563-+

[17] Mismatch repair deficient colorectal cancer in the era of personalized treatment [J].

Hewish, Madeleine ;

Lord, Christopher J. ;

Martin, Sarah A. ;

Cunningham, David ;

Ashworth, Alan .

NATURE REVIEWS CLINICAL ONCOLOGY, 2010, 7 (04) :197-208

[18] A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy [J].

Hunter, C ;

Smith, R ;

Cahill, DP ;

Stephens, P ;

Stevens, C ;

Teague, J ;

Greenman, C ;

Edkins, S ;

Bignell, G ;

Davies, H ;

O'Meara, S ;

Parker, A ;

Avis, T ;

Barthorpe, S ;

Brackenbury, L ;

Buck, G ;

Butler, A ;

Clements, J ;

Cole, J ;

Dicks, E ;

Forbes, S ;

Gorton, M ;

Gray, K ;

Halliday, K ;

Harrison, R ;

Hills, K ;

Hinton, J ;

Jenkinson, A ;

Jones, D ;

Kosmidou, V ;

Laman, R ;

Lugg, R ;

Menzies, A ;

Perry, J ;

Petty, R ;

Raine, K ;

Richardson, D ;

Shepherd, R ;

Small, A ;

Solomon, H ;

Tofts, C ;

Varian, J ;

West, S ;

Widaa, S ;

Yates, A ;

Easton, DF ;

Riggins, G ;

Roy, JE ;

Levine, KK ;

Mueller, W .

CANCER RESEARCH, 2006, 66 (08) :3987-3991

[19] Role of MGMT as biomarker in colorectal cancer [J].

Inno, Alessandro ;

Fanetti, Giuseppe ;

Di Bartolomeo, Maria ;

Gori, Stefania ;

Maggi, Claudia ;

Cirillo, Massimo ;

Iacovelli, Roberto ;

Nichetti, Federico ;

Martinetti, Antonia ;

de Braud, Filippo ;

Bossi, Ilaria ;

Pietrantonio, Filippo .

WORLD JOURNAL OF CLINICAL CASES, 2014, 2 (12) :835-839

[20]

Jemal A, 2009, CA-CANCER J CLIN, V59, P225, DOI [10.3322/caac.20006, 10.3322/caac.21254, 10.3322/caac.21332, 10.3322/caac.21551, 10.3322/caac.20073, 10.3322/caac.21387, 10.3322/caac.21654, 10.3322/caac.21601]

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