Breast-feeding after transplantation

被引：88

作者：

Constantinescu, Serban ^{[1
]}

Pai, Akshta ^{[1
]}

Coscia, Lisa A. ^{[2
]}

Davison, John M. ^{[3
]}

Moritz, Michael J. ^{[4
,5
]}

Armenti, Vincent T. ^{[2
,6
]}

机构：

[1] Temple Univ, Sch Med, Philadelphia, PA 19140 USA

[2] Gift Life Inst, Natl Transplantat Pregnancy Registry, Philadelphia, PA 19123 USA

[3] Fac Med Sci, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[4] Lehigh Valley Hosp, Allentown, PA 18103 USA

[5] Univ S Florida, Morsani Coll Med, Tampa, FL USA

[6] Univ Cent Florida, Orlando, FL 32816 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2014年 / 28卷 / 08期

关键词：

immunosuppression; breast-feeding; transplant; breast milk; lactation; BIRTH-WEIGHT INFANTS; INTENSIVE-CARE-UNIT; FOLLOW-UP; ANTENATAL CORTICOSTEROIDS; MYCOPHENOLATE-MOFETIL; MILK; TACROLIMUS; CYCLOSPORINE; PREGNANCY; AZATHIOPRINE;

D O I：

10.1016/j.bpobgyn.2014.09.001

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Transplantation affords recipients the potential for a full life and, for some, parenthood. Female transplant recipients must continue to take immunosuppression during pregnancy and breast-feeding. This article reviews case and series reports regarding breast-feeding in those taking transplant medications. Avoidance of breast-feeding has been the customary advice because of the potential adverse effects of immunosuppressive exposure on the infant. Subsequent studies have demonstrated that not all medication exposure translates to risk for the infant, that the exposure in utero is greater than via breast milk and that no lingering effects due to breast-feeding have been found to date in infants who were breast-fed while their mothers were taking prednisone, azathioprine, cyclosporine, and/or tacrolimus. Thus, except for those medications where clinical information is inadequate (mycophenolic acid products, sirolimus, everolimus, and belatacept), the recommendation for transplant recipients regarding breastfeeding has evolved into one that is cautiously optimistic. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1163 / 1173

页数：11

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