Genetics of breast cancer: management strategies and risk-reducing surgery

被引：24

作者：

Balasubramanian, Rajesh ^{[1
]}

Rolph, Rachel ^{[1
]}

Morgan, Catrin ^{[1
]}

Hamed, Hisham ^{[1
]}

机构：

[1] Guys & St Thomas NHS Fdn Trust, Dept Breast Surg, London SE1 7EH, England

来源：

BRITISH JOURNAL OF HOSPITAL MEDICINE | 2019年 / 80卷 / 12期

关键词：

BRCA2 MUTATION CARRIERS; COLLABORATIVE REANALYSIS; INDIVIDUAL DATA; POSTMENOPAUSAL WOMEN; FOLLOW-UP; ESTROGEN; METAANALYSIS; PREVENTION; SMOKING; ATM;

D O I：

10.12968/hmed.2019.80.12.720

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The last two decades have witnessed major advances in genetic sequencing which have led to more accurate identification of women at risk of developing breast cancer and calculating the associated cancer risk. This review discusses the current genetic mutations conferring risk of developing breast cancer and the management pathway for these women with identifiable mutations as well as those with a strong family history for breast cancer. Management of these individuals is complex and should involve a multidisciplinary team with interest and expertise in breast cancer genetics. There are several treatment options ranging from surveillance to risk-reducing surgery. Risk reduction surgery has been popularised by celebrities who are carriers of breast cancer genes, and raised public awareness of breast cancer genetics and associated risk.

引用

页码：720 / 725

页数：6

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