A Multicomponent One-pot Synthesis of 3-Cyanopyridine Derivatives

被引：0
|
作者：
Al-Ghorbani, Mohammed [1 ,2 ]
Gouda, Moustafa A. [1 ,3 ]
Qurban, Jihan [4 ]
机构：
[1] Taibah Univ, Ulla Sci & Arts Coll, Dept Chem, Medina, Saudi Arabia
[2] Thamar Univ, Coll Educ, Dept Chem, Dhamar, Yemen
[3] Mansoura Univ, Fac Sci, Dept Chem, El Gomhoria St, Mansoura, Egypt
[4] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Mecca, Saudi Arabia
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 01期
关键词：
3-Cyanopyridine; Malononitrile; Ethyl cyanoacetate; Multicomponent one-pot synthesis; DISCOVERY; INHIBITORS; DESIGN;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient method was developed for synthesis of 2-amino-3-cyanopyridine and 3-cyanopyridine-2(1H)-ones (4a-e, 6a-e) from 2,6-dimethylheptan-4-one, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in the presence of ammonium acetate in good to excellent yields and the structure of targets compounds was characterized by Fourier-transform infrared and H-1 and C-13 nuclear magnetic resonance and mass spectral and elemental analytical data.
引用
收藏
页码：77 / 80
页数：4
相关论文
共 50 条
  • [1] One-pot synthesis and antimicrobial evaluation of novel 3-cyanopyridine derivatives of (-)-β-pinene
    Liao, Shengliang
    Shang, Shibin
    Shen, Minggui
    Rao, Xiaoping
    Si, Hongyan
    Song, Jie
    Song, Zhanqian
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (06) : 1512 - 1515
  • [2] Application of Heteropolyacids as Heterogeneous and Recyclable Catalysts for One-Pot Synthesis of 3-Cyanopyridine Derivatives
    Heravi, Majid M.
    Beheshtia, Yahya S.
    Khorshidi, Maliheh
    Baghernejad, Bita
    Bamoharram, Fatemeh F.
    CHINESE JOURNAL OF CHEMISTRY, 2009, 27 (03) : 569 - 572
  • [3] One-pot synthesis of 2-amino-3-cyanopyridine derivatives under solvent-free conditions
    Ghorbani-Vaghei, Ramin
    Toghraei-Semiromi, Zahra
    Karimi-Nami, Rahman
    COMPTES RENDUS CHIMIE, 2013, 16 (12) : 1111 - 1117
  • [4] A Dynamic Multicomponent Approach for One-Pot Synthesis of 3-Thioisoindolinones
    Sakulsombat, Morakot
    Angelin, Marcus
    Caraballo, Remi
    Ramstrom, Olof
    ISRAEL JOURNAL OF CHEMISTRY, 2013, 53 (1-2) : 127 - 132
  • [5] One-pot synthesis of 2-amino-3-cyanopyridine derivatives catalyzed by ytterbium perfluorooctanoate [Yb(PFO)3]
    Tang, Jun
    Wang, Limin
    Yao, Yinfang
    Zhang, Liang
    Wang, Wenbo
    TETRAHEDRON LETTERS, 2011, 52 (04) : 509 - 511
  • [6] Design and synthesis of new series of 3-cyanopyridine and pyrazolopyridine derivatives
    Keshk, Reda Mohammed
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (09) : 3384 - 3393
  • [7] One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives
    Sawant, Sanghapal D.
    Srinivas, Mahesuni
    Reddy, G. Lakshma
    Rao, V. Venkateswar
    Singh, Parvinder Pal
    Vishwakarma, Ram A.
    TETRAHEDRON LETTERS, 2012, 53 (46) : 6195 - 6198
  • [8] One-pot multicomponent synthesis of novel thiazolylhydrazone derivatives and their antimicrobial activity
    Rajitha, G.
    Ravibabu, V.
    Ramesh, G.
    Rajitha, B.
    Jobina, R.
    Siddhardha, B.
    Laxmi, S. Vijaya
    RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (12) : 9703 - 9713
  • [9] One-pot synthesis of iodoindolizine derivatives via a novel multicomponent reaction
    Yan, Peiyun
    Liu, Juanjuan
    Sun, Qian
    Yao, Juan
    Xue, Zhiheng
    Wang, Cunde
    JOURNAL OF CHEMICAL RESEARCH, 2013, (06) : 323 - 326
  • [10] Iodine catalyzed synthesis of the chromene derivatives in one-pot
    Zeng, Li Yan
    Lv, Mei Fang
    Cai, Chun
    CHINESE CHEMICAL LETTERS, 2012, 23 (12) : 1347 - 1351
12345