Elucidating the DDK-dependent step in replication initiation

被引：10
|
作者：
Araki, Hiroyuki [1 ]
机构：
[1] Natl Inst Genet, Mishima, Shizuoka 411, Japan
来源：
EMBO JOURNAL | 2016年 / 35卷 / 09期
关键词：
CHROMOSOMAL DNA-REPLICATION; PROTEINS; SLD3; YEAST;
D O I：
10.15252/embj.201694227
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
By phosphorylating specific replication factors, cell cycle kinases ensure that eukaryotic DNA replication is initiated once and only once per mitotic cell division. New work in The EMBO Journal now reveals how DDK-mediated phosphorylation of Mcm2-7 helicase subunits is read out by Sld3, which provides further integration with CDK phosphorylation.
引用
收藏
页码：907 / 908
页数：2
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