Prevalence of ESKAPE pathogens in the environment: Antibiotic resistance status, community-acquired infection and risk to human health

被引：196

作者：

Denissen, Julia ^{[1
]}

Reyneke, Brandon ^{[1
]}

Waso-Reyneke, Monique ^{[2
]}

Havenga, Benjamin ^{[1
]}

Barnard, Tobias ^{[3
]}

Khan, Sehaam ^{[2
]}

Khan, Wesaal ^{[1
]}

机构：

[1] Stellenbosch Univ, Fac Sci, Dept Microbiol, Private Bag X1, ZA-7602 Stellenbosch, South Africa

[2] Univ Johannesburg, Fac Hlth Sci, POB 17011, ZA-2028 Doornfontein, South Africa

[3] Univ Johannesburg, Water & Hlth Res Ctr, POB 17011, ZA-7305 Doornfontein, South Africa

来源：

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH | 2022年 / 244卷

关键词：

ESKAPE pathogens; Environment; Antibiotic resistance; Community -acquired infection; Risk assessment; STAPHYLOCOCCUS-AUREUS INFECTIONS; LEVEL GLYCOPEPTIDE RESISTANCE; ENTEROCOCCUS-FAECIUM STRAINS; SPECTRUM BETA-LACTAMASE; BLOOD-STREAM INFECTION; ANTIMICROBIAL RESISTANCE; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; FOOD-ANIMALS; WASTE-WATER;

D O I：

10.1016/j.ijheh.2022.114006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseu-domonas aeruginosa, and Enterobacter spp.) pathogens are characterised by increased levels of resistance towards multiple classes of first line and last-resort antibiotics. Although these pathogens are frequently isolated from clinical environments and are implicated in a variety of life-threatening, hospital-associated infections; antibiotic resistant ESKAPE strains have been isolated from environmental reservoirs such as surface water, wastewater, food, and soil. Literature on the persistence and subsequent health risks posed by the ESKAPE isolates in extra -hospital settings is however, limited and the current review aims to elucidate the primary reservoirs of these pathogens in the environment, their antibiotic resistance profiles, and the link to community-acquired infections. Additionally, information on the current state of research regarding health-risk assessments linked to exposure of the ESKAPE pathogens in the natural environment, is outlined.

引用

页数：17

共 192 条

[1] Quantitative microbial risk assessment (QMRA) shows increased public health risk associated with exposure to river water under conditions of riverbed sediment resuspension [J].