Increased risk of high-grade prostate cancer among testicular cancer survivors

被引:0
|
作者
Zhang, Hong [1 ]
Yang, Hongmei [2 ]
Bandyopadhyay, Sanjukta [2 ]
Milano, Michael T. [1 ]
Fung, Chunkit [3 ]
Messing, Edward M. [4 ]
Chen, Yuhchyau [1 ]
机构
[1] Univ Rochester, Med Ctr, Dept Radiat Oncol, Rochester, NY 14642 USA
[2] Univ Rochester, Med Ctr, Dept Biostat & Computat Biol, Rochester, NY 14642 USA
[3] Univ Rochester, Med Ctr, Dept Med, Div Hematol & Oncol, Rochester, NY 14642 USA
[4] Univ Rochester, Med Ctr, Dept Urol, Rochester, NY 14642 USA
来源
PLOS ONE | 2022年 / 17卷 / 02期
关键词
STAGE; SEMINOMA;
D O I
10.1371/journal.pone.0263573
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Introduction Testicular cancer survivors (TCS) have an increased risk of additional cancers, including prostate cancer. Our understanding of the natural history of prostate cancer in testicular cancer survivors is very limited due to its rare incidence. Methods Using the Surveillance, Epidemiology, and End Results (SEER) Registry from 1978 to 2011, we identified 282 TCS with subsequent prostate cancer and examined the tumor grade and clinical outcomes in contrast to men with primary prostate cancer in the general population. Results TCS with a subsequent prostate cancer diagnosis were more likely to be diagnosed at a younger age than men with primary prostate cancer (65.2% vs. 37.6% for age <65, 34.8% vs. 62.4% for age >65, p<0.001) and were more likely to have grade III/IV tumors (46.2% vs. 37.0%, p<0.002). Longer latency between testicular and prostate cancer diagnoses was associated with a higher risk of grade III/IV (p<0.001) cancer. Despite the increased risk for high-grade tumors, 10-year prostate cancer-specific survival and overall survival were not significantly different between TCS and men with primary prostate cancer. Based on the available information in SEER, we found that prior history of radiotherapy for testicular cancer had no impact on tumor grade or survival outcomes. Conclusions Prostate cancer in TCS was more likely to be diagnosed at a younger age and with higher grades. Risks of grade III/IV disease increased with longer latency between testicular and prostate cancer diagnoses. Radiotherapy for testicular cancer did not appear to have a significant impact on the outcome of subsequent prostate cancer.
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页数:10
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