'Unleashed' natural killers hinder HIV

被引：27

作者：

Altfeld, Marcus

Goulder, Philip

机构：

[1] Massachusetts Gen Hosp, AIDS Res Ctr, Charlestown, MA 02129 USA

[2] Univ Oxford, AIDS Res Ctr, Oxford OX1 3SY, England

[3] Univ Oxford, Dept Paediat, Oxford OX1 3SY, England

来源：

NATURE GENETICS | 2007年 / 39卷 / 06期

关键词：

IMMUNOGLOBULIN-LIKE RECEPTORS; NK CELLS; CUTTING EDGE; HLA-B; POLYMORPHISMS; PROGRESSION; PROTEINS; KIR3DL1; AIDS;

D O I：

10.1038/ng0607-708

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A new study reports that specific combinations of killer immunoglobulin-like receptor and HLA-B alleles influence AIDS progression and plasma HIV RNA levels in HIV-infected individuals. These results suggest that natural killer cells have an important role in recognizing and limiting HIV infection.

引用

页码：708 / 710

页数：4

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