Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein

被引：67
作者：
Akiyama, H [1 ]
Schwab, C [1 ]
Kondo, H [1 ]
Mori, H [1 ]
Kametani, F [1 ]
Ikeda, K [1 ]
McGeer, PL [1 ]
机构：
[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER,BC V6T 1W5,CANADA
来源：
NEUROSCIENCE LETTERS | 1996年 / 206卷 / 2-3期
关键词：
beta-amyloid protein (A beta); microglia; astrocytes; phagocytosis; proteolysis; immunohistochemistry;
D O I：
10.1016/S0304-3940(96)12474-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Granular structures that are recognized by antibodies specific for the C-terminal but not the N-terminal sequences of the beta-amyloid protein (A beta) fragments are present in a subset of microglia and astrocytes in Alzheimer brain tissue. The immunohistochemical profile indicates that the A beta in these granules is truncated between the residues 17 and 31 and terminates at the residue 42 or 43, Such granule-containing glia occur only in brain areas with the heavy A beta deposits. Whether the intraglial A beta fragments accumulate as a result of phagocytosis of extracellular A beta or are formed intracellularly by glial cells from amyloid precursor protein (APP) remains unknown.
引用
收藏
页码：169 / 172
页数：4
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