Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein

被引：67

作者：

Akiyama, H ^{[1
]}

Schwab, C ^{[1
]}

Kondo, H ^{[1
]}

Mori, H ^{[1
]}

Kametani, F ^{[1
]}

Ikeda, K ^{[1
]}

McGeer, PL ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER,BC V6T 1W5,CANADA

来源：

NEUROSCIENCE LETTERS | 1996年 / 206卷 / 2-3期

关键词：

beta-amyloid protein (A beta); microglia; astrocytes; phagocytosis; proteolysis; immunohistochemistry;

D O I：

10.1016/S0304-3940(96)12474-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Granular structures that are recognized by antibodies specific for the C-terminal but not the N-terminal sequences of the beta-amyloid protein (A beta) fragments are present in a subset of microglia and astrocytes in Alzheimer brain tissue. The immunohistochemical profile indicates that the A beta in these granules is truncated between the residues 17 and 31 and terminates at the residue 42 or 43, Such granule-containing glia occur only in brain areas with the heavy A beta deposits. Whether the intraglial A beta fragments accumulate as a result of phagocytosis of extracellular A beta or are formed intracellularly by glial cells from amyloid precursor protein (APP) remains unknown.

引用

页码：169 / 172

页数：4

共 47 条

[21] Molecular identification of protein kinase C beta in Alzheimer's disease
Zhou, Zhike
Chen, Fenqin
Zhong, Shanshan
Zhou, Yi
Zhang, Rongwei
Kang, Kexin
Zhang, Xiaoqian
Xu, Ying
Zhao, Mei
Zhao, Chuansheng
AGING-US, 2020, 12 (21): : 21798 - 21808
[22] BETA-AMYLOID STIMULATES GLIAL-CELLS INVITRO TO PRODUCE GROWTH-FACTORS THAT ACCUMULATE IN SENILE PLAQUES IN ALZHEIMERS-DISEASE
ARAUJO, DM
COTMAN, CW
BRAIN RESEARCH, 1992, 569 (01) : 141 - 145
[23] Glial Fibrillary Acidic Protein and Protein S-100B: Different Concentration Pattern of Glial Proteins in Cerebrospinal Fluid of Patients with Alzheimer's Disease and Creutzfeldt-Jakob Disease
Jesse, Sarah
Steinacker, Petra
Cepek, Lukas
von Arnim, Christine A. F.
Tumani, Hayrettin
Lehnert, Stefan
Kretzschmar, Hans A.
Baier, Michael
Otto, Markus
JOURNAL OF ALZHEIMERS DISEASE, 2009, 17 (03) : 541 - 551
[24] The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease
Collins, Jessica M.
King, Anna E.
Woodhouse, Adele
Kirkcaldie, Matthew T. K.
Vickers, James C.
EXPERIMENTAL NEUROLOGY, 2015, 267 : 219 - 229
[25] Impact of alternating amino acid sequences on beta-amyloid-induced neurotoxicity and neuroinflammation in Alzheimer's disease
Li, Zhixin
Peng, Minqi
Wang, Chen
Yang, Jiaan
Li, Xiang
Zhao, Jing
AGING-US, 2023, 15 (19): : 10580 - 10592
[26] BETA-AMYLOID REGULATES GENE-EXPRESSION OF GLIAL TROPHIC SUBSTANCE S100-BETA IN C6 GLIOMA AND PRIMARY ASTROCYTE CULTURES
PENA, LA
BRECHER, CW
MARSHAK, DR
MOLECULAR BRAIN RESEARCH, 1995, 34 (01): : 118 - 126
[27] The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis
Kouchi, Z
Kinouchi, T
Sorimachi, H
Ishiura, S
Suzuki, K
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 258 (02): : 291 - 300
[28] RAPID APPEARANCE OF BETA-AMYLOID PRECURSOR PROTEIN IMMUNOREACTIVITY IN DAMAGED AXONS AND REACTIVE GLIAL-CELLS IN RAT-BRAIN FOLLOWING NEEDLE STAB INJURY
OTSUKA, N
TOMONAGA, M
IKEDA, K
BRAIN RESEARCH, 1991, 568 (1-2) : 335 - 338
[29] EXPRESSION OF CARBOXY-TERMINAL REGION OF THE BETA-AMYLOID PRECURSOR PROTEIN IN A HETEROGENEOUS CULTURE OF NEUROBLASTOMA-CELLS - EVIDENCE FOR ALTERED PROCESSING AND SELECTIVE NEUROTOXICITY
FUKUCHI, K
KAMINO, K
DEEB, SS
FURLONG, CE
SUNDSTROM, JA
SMITH, AC
MARTIN, GM
MOLECULAR BRAIN RESEARCH, 1992, 16 (1-2): : 37 - 46
[30] Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease
Yasojima, K
Schwab, C
McGeer, EG
McGeer, PL
BRAIN RESEARCH, 2000, 887 (01) : 80 - 89

← 1 2 3 4 5 →