Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of beta-amyloid protein

被引：67

作者：

Akiyama, H ^{[1
]}

Schwab, C ^{[1
]}

Kondo, H ^{[1
]}

Mori, H ^{[1
]}

Kametani, F ^{[1
]}

Ikeda, K ^{[1
]}

McGeer, PL ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER,BC V6T 1W5,CANADA

来源：

NEUROSCIENCE LETTERS | 1996年 / 206卷 / 2-3期

关键词：

beta-amyloid protein (A beta); microglia; astrocytes; phagocytosis; proteolysis; immunohistochemistry;

D O I：

10.1016/S0304-3940(96)12474-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Granular structures that are recognized by antibodies specific for the C-terminal but not the N-terminal sequences of the beta-amyloid protein (A beta) fragments are present in a subset of microglia and astrocytes in Alzheimer brain tissue. The immunohistochemical profile indicates that the A beta in these granules is truncated between the residues 17 and 31 and terminates at the residue 42 or 43, Such granule-containing glia occur only in brain areas with the heavy A beta deposits. Whether the intraglial A beta fragments accumulate as a result of phagocytosis of extracellular A beta or are formed intracellularly by glial cells from amyloid precursor protein (APP) remains unknown.

引用

页码：169 / 172

页数：4

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