Functional characteristics of heterologously expressed 5-HT receptors

被引：161

作者：

Gerhardt, CC ^{[1
]}

vanHeerikhuizen, H ^{[1
]}

机构：

[1] VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,DEPT BIOCHEM & MOL BIOL,NL-1018 HV AMSTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 334卷 / 01期

关键词：

5-HT; (5-hydroxytryptamine; serotonin); 5-HT receptor; G-protein-coupled receptor; signal transduction;

D O I：

10.1016/S0014-2999(97)01115-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past 10 years, molecular cloning has revealed the presence of 15 serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except for the 5-HT3, receptors, which are ligand-gated ion channels, all 5-HT receptors belong to the superfamily of G-protein-coupled receptors. The large multiplicity of 5-HT receptor subtypes has been suggested to lie a direct result of the evolutionary age of the 5-HT system, Molecular information on G-protein-coupled 5-HT receptors is: currently available for several mammalian species as well as for a limited number of invertebrate species (insects, molluscs), The aim of this review is to give an overview of all cloned 5-HT receptor subtypes belonging to the superfamily of G-protein-coupled receptors with specific emphasis on the pharmacological and signaling properties of the receptors upon expression in several heterologous expression systems. (C) 1997 Elsevier Science B.V.

引用

页码：1 / 23

页数：23

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