Functional characteristics of heterologously expressed 5-HT receptors

被引:161
作者
Gerhardt, CC [1 ]
vanHeerikhuizen, H [1 ]
机构
[1] VRIJE UNIV AMSTERDAM,NEUROSCI RES INST,DEPT BIOCHEM & MOL BIOL,NL-1018 HV AMSTERDAM,NETHERLANDS
关键词
5-HT; (5-hydroxytryptamine; serotonin); 5-HT receptor; G-protein-coupled receptor; signal transduction;
D O I
10.1016/S0014-2999(97)01115-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Over the past 10 years, molecular cloning has revealed the presence of 15 serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except for the 5-HT3, receptors, which are ligand-gated ion channels, all 5-HT receptors belong to the superfamily of G-protein-coupled receptors. The large multiplicity of 5-HT receptor subtypes has been suggested to lie a direct result of the evolutionary age of the 5-HT system, Molecular information on G-protein-coupled 5-HT receptors is: currently available for several mammalian species as well as for a limited number of invertebrate species (insects, molluscs), The aim of this review is to give an overview of all cloned 5-HT receptor subtypes belonging to the superfamily of G-protein-coupled receptors with specific emphasis on the pharmacological and signaling properties of the receptors upon expression in several heterologous expression systems. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:1 / 23
页数:23
相关论文
共 192 条
[1]   CONDITIONAL TRANSFORMATION MEDIATED VIA A PERTUSSIS TOXIN-SENSITIVE RECEPTOR SIGNALING PATHWAY [J].
ABDELBASET, H ;
BOZOVIC, V ;
SZYF, M ;
ALBERT, PR .
MOLECULAR ENDOCRINOLOGY, 1992, 6 (05) :730-740
[2]  
ABDUL M, 1994, ANTICANCER RES, V14, P1215
[3]   CELL-SPECIFIC COUPLING OF THE CLONED HUMAN 5-HT(1F) RECEPTOR TO MULTIPLE SIGNAL-TRANSDUCTION PATHWAYS [J].
ADHAM, N ;
BORDEN, LA ;
SCHECHTER, LE ;
GUSTAFSON, EL ;
COCHRAN, TL ;
VAYSSE, PJJ ;
WEINSHANK, RL ;
BRANCHEK, TA .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1993, 348 (06) :566-575
[4]  
ADHAM N, 1992, MOL PHARMACOL, V41, P1
[5]   CLONING OF ANOTHER HUMAN SEROTONIN RECEPTOR (5-HT1F) - A 5TH 5-HT1 RECEPTOR SUBTYPE COUPLED TO THE INHIBITION OF ADENYLATE-CYCLASE [J].
ADHAM, N ;
KAO, HT ;
SCHECHTER, LE ;
BARD, J ;
OLSEN, M ;
URQUHART, D ;
DURKIN, M ;
HARTIG, PR ;
WEINSHANK, RL ;
BRANCHEK, TA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :408-412
[6]   THE CLONED HUMAN 5-HT1E RECEPTOR COUPLES TO INHIBITION AND ACTIVATION OF ADENYLYL-CYCLASE VIA 2 DISTINCT PATHWAYS IN TRANSFECTED BS-C-1 CELLS [J].
ADHAM, N ;
VAYSSE, PJJ ;
WEINSHANK, RL ;
BRANCHEK, TA .
NEUROPHARMACOLOGY, 1994, 33 (3-4) :403-410
[7]  
AKIYOSHI J, 1995, J NEUROCHEM, V64, P2473
[8]  
ALAMULA N, 1996, J BIOL CHEM, V271, P14672
[9]  
ALBERT PR, 1990, J BIOL CHEM, V265, P5825
[10]  
AMLAIKY N, 1992, J BIOL CHEM, V267, P19761