Enhanced in situ detection and imaging of lipids in biological tissues by using 2,3-dicyanohydroquinone as a novel matrix for positive-ion MALDI-MS imaging

被引：39

作者：

Liu, Yaqin ^{[1
,2
]}

Chen, Lulu ^{[2
]}

Qin, Liang ^{[2
]}

Han, Manman ^{[1
,2
]}

Li, Jinming ^{[1
,2
]}

Luo, Feixian ^{[2
]}

Xue, Kun ^{[2
]}

Feng, Jinchao ^{[2
]}

Zhou, Yijun ^{[2
]}

Wang, Xiaodong ^{[1
,2
]}

机构：

[1] Minzu Univ China, Ctr Imaging & Syst Biol, Beijing 100081, Peoples R China

[2] Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 83期

基金：

中国国家自然科学基金;

关键词：

MASS-SPECTROMETRY; MOUSE-BRAIN; PHOSPHOLIPIDS;

D O I：

10.1039/c9cc06961e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A fluorescent dye, 2,3-dicyanohydroquinone (DCH), was optimized for use as a new matrix for positive-ion MALDI-MS imaging, and it provided enhanced lipid detection and imaging in biological tissues. The properties of DCH, include a strong ultraviolet absorption, low volatility in a high-vacuum (similar to 10(-7) mbar) source, super chemical stability, mu m-sized matrix crystals, uniform matrix deposition, and high ionization efficiency for the detection of lipids.

引用

页码：12559 / 12562

页数：4

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