The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study

被引：51

作者：

Kohli, Indermeet ^{[1
]}

Shafi, Rubina ^{[2
]}

Isedeh, Prescilia ^{[1
]}

Griffith, James L. ^{[1
]}

Al-Jamal, Mohammed S. ^{[1
]}

Silpa-archa, Narumol ^{[1
]}

Jackson, Bradford ^{[2
]}

Athar, Mohammed ^{[2
]}

Kollias, Nikiforos

Elmets, Craig A. ^{[2
]}

Lim, Henry W. ^{[1
]}

Hamzavi, Iltefat H. ^{[1
]}

机构：

[1] Henry Ford Hosp, Dept Dermatol, Multicultural Dermatol Ctr, New Ctr One,3031 W Grand Blvd,Suite 800, Detroit, MI 48202 USA

[2] Univ Alabama Birmingham, Dept Dermatol, Birmingham, AL USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2017年 / 77卷 / 01期

关键词：

colorimetry; cyclobutane pyrimidine dimers; excimer laser; minimal erythema dose; Polypodium leucotomos extract; sunburn cells; ultraviolet; VISIBLE-LIGHT; SKIN; ERYTHEMA; TRIAL; UVB; PIGMENTATION; PREVENTION; VITILIGO;

D O I：

10.1016/j.jaad.2017.01.044

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. Objective: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). Methods: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE. Results: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects. Limitations: Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied. Conclusion: The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.

引用

页码：33 / +

页数：10

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